GPER

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GPER

A gene on chromosome 7p22.3 that encodes a G protein-coupled receptor that binds oestrogen and is widely distributed in neural, breast cancer, placental, heart, ovarian, prostate, hepatic, vascular epithelial and lymphoid tissue. It plays a role in rapid nongenomic signalling events seen after oestrogen stimulation of cells and tissues.

References in periodicals archive ?

Barton, "The G-protein-coupled estrogen receptor GPER in health and disease," Nature Reviews Endocrinology, vol.

Estrogen: an emerging regulator of insulin action and mitochondrial function

In addition, GPER is also highly expressed in human macrophages [201].

Estrogen signaling in metabolic inflammation

Because of the lack of specificity of estrogen and anti-estrogens for the three known estrogen receptors (ER[alpha], ER[beta], and GPER), we have developed both a GPER-selective agonist (G-1, [40]) and antagonists (G15 [41]and G36[42]) that display virtually no activity towards the classical estrogen receptors.

G protein-coupled estrogen receptor-selective ligands modulate endometrial tumor growth

In the present study, we quantified the GPER binding potencies of 12 PBDEs (with bromination numbers from 1 to 8) and 18 OH-PBDEs (with hydroxyl positions of ortho-, meta- and para-) using a fluorescence competitive binding assay in a human breast cancer cell line (SKBR3).

Hydroxylated Polybrominated Biphenyl Ethers Exert Estrogenic Effects via Non-Genomic G Protein-Coupled Estrogen Receptor Mediated Pathways

Primer sequences for GPER and GAPDH are presented in Table 1.

Expression Pattern of G-Protein-Coupled Estrogen Receptor in Myometrium of Uteri with and without Adenomyosis

A growing body of evidence suggests that these effects cannot be explained solely by the classical model of steroid hormone action and that 17[beta]-estradiol can also mediate rapid signaling events via pathways that involve transmembrane ERs, such as G-protein-coupled estrogen receptor termed GPER (Prossnitz et al.

Estrogen receptor alpha augments changes in hemostatic gene expression in HepG2 cells treated with estradiol and phytoestrogens

But, pondering some of the Gper i b deeper meanings behind the act of sending mundane messages to thousands of people she's never met, she asks, rhetorically: "Do we think we're funnier than we actually are when on twitter?" " Undoubtedly, Geri, you're a comedyy gem - but unintentionally.

life tweet The Spice ter of Twit; everything SHARES.. geri halliwell

Zingg et al., "Estrogen receptor-[alpha] but not-[beta] or GPER inhibits high glucose-induced human VSMC proliferation: potential role of ROS and ERK," Journal of Clinical Endocrinology and Metabolism, vol.

Paeonol inhibits proliferation of vascular smooth muscle cells stimulated by high glucose via Ras-Raf-ERK1/2 signaling pathway in coculture model

mention, 17[beta]-estradiol ([E.sub.2]) inhibited cell proliferation through estrogen receptor (ER) P in human testicular seminoma-derived JKT-1 cells and seminoma tumors, whereas bisphenol A (BPA) promoted growth responses through G protein-coupled estrogen receptor (GPER) and the activation of protein kinase A and protein kinase G transduction pathways, but not through extracellular-signal-regulated kinase (ERK) signaling (Bouskine et al.

Comment on "effects of trazine on estrogen receptor [alpha]- and G protein-coupled receptor 30-mediated signaling and proliferation in cancer cells and cancer-associated Fibroblasts"

mention, 17[beta]-estradiol ([E.sub.2]) inhibited cell proliferation through estrogen receptor (ER) [beta] in human testicular seminoma-derived JKT-1 cells and seminoma tumors, whereas bisphenol A (BPA) promoted growth responses through G protein-coupled estrogen receptor (GPER) and the activation of protein kinase A and protein kinase G transduction pathways, but not through extracellular-signal-regulated kinase (ERK) signaling (Bouskine et al.

Comment on "Effects of atrazine on estrogen receptor [alpha]- and G protein-coupled receptor 30-mediated signaling and proliferation in cancer cells and cancer-associated fibroblasts"

In this regard, our study and others have demonstrated that GPER is involved in multiple actions triggered by estrogenic compounds, including environmental contaminants, in a variety of cancer cells as well as in cancer-associated fibroblasts (CAFs) (Albanito et al.

Effects of atrazine on estrogen receptor [alpha]- and G protein-coupled receptor 30-mediated signaling and proliferation in cancer cells and cancer-associated fibroblasts