GPER


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GPER

A gene on chromosome 7p22.3 that encodes a G protein-coupled receptor that binds oestrogen and is widely distributed in neural, breast cancer, placental, heart, ovarian, prostate, hepatic, vascular epithelial and lymphoid tissue. It plays a role in rapid nongenomic signalling events seen after oestrogen stimulation of cells and tissues.
References in periodicals archive ?
Barton, "The G-protein-coupled estrogen receptor GPER in health and disease," Nature Reviews Endocrinology, vol.
In addition, GPER is also highly expressed in human macrophages [201].
Because of the lack of specificity of estrogen and anti-estrogens for the three known estrogen receptors (ER[alpha], ER[beta], and GPER), we have developed both a GPER-selective agonist (G-1, [40]) and antagonists (G15 [41]and G36[42]) that display virtually no activity towards the classical estrogen receptors.
Assim, o posicionamento do GPER e marcadamente favoravel ao ensino religioso--nao necessariamente ao modelo confessional--como um 'conteudo importante' nao apenas para a 'formacao' do individuo, mas como um 'fomentador do dialogo' entre culturas e tendencias diferentes--em resposta ao simulacro dos defensores da laicizacao, cuja FD aponta o contrario--e, sobretudo, um 'direito' do educando.
In the present study, we quantified the GPER binding potencies of 12 PBDEs (with bromination numbers from 1 to 8) and 18 OH-PBDEs (with hydroxyl positions of ortho-, meta- and para-) using a fluorescence competitive binding assay in a human breast cancer cell line (SKBR3).
A growing body of evidence suggests that these effects cannot be explained solely by the classical model of steroid hormone action and that 17[beta]-estradiol can also mediate rapid signaling events via pathways that involve transmembrane ERs, such as G-protein-coupled estrogen receptor termed GPER (Prossnitz et al.
But, pondering some of the Gper i b deeper meanings behind the act of sending mundane messages to thousands of people she's never met, she asks, rhetorically: "Do we think we're funnier than we actually are when on twitter?" " Undoubtedly, Geri, you're a comedyy gem - but unintentionally.
Zingg et al., "Estrogen receptor-[alpha] but not-[beta] or GPER inhibits high glucose-induced human VSMC proliferation: potential role of ROS and ERK," Journal of Clinical Endocrinology and Metabolism, vol.
mention, 17[beta]-estradiol ([E.sub.2]) inhibited cell proliferation through estrogen receptor (ER) P in human testicular seminoma-derived JKT-1 cells and seminoma tumors, whereas bisphenol A (BPA) promoted growth responses through G protein-coupled estrogen receptor (GPER) and the activation of protein kinase A and protein kinase G transduction pathways, but not through extracellular-signal-regulated kinase (ERK) signaling (Bouskine et al.
mention, 17[beta]-estradiol ([E.sub.2]) inhibited cell proliferation through estrogen receptor (ER) [beta] in human testicular seminoma-derived JKT-1 cells and seminoma tumors, whereas bisphenol A (BPA) promoted growth responses through G protein-coupled estrogen receptor (GPER) and the activation of protein kinase A and protein kinase G transduction pathways, but not through extracellular-signal-regulated kinase (ERK) signaling (Bouskine et al.
In this regard, our study and others have demonstrated that GPER is involved in multiple actions triggered by estrogenic compounds, including environmental contaminants, in a variety of cancer cells as well as in cancer-associated fibroblasts (CAFs) (Albanito et al.