GPBAR1

(redirected from GPCR)
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GPBAR1

A gene on chromosome 2q35 that encodes a G protein-coupled receptor for bile acid. Bile acid binding induces GPBAR1 internalisation, activation of extracellular signal-regulated kinase and intracellular cAMP production; it is believed to be involved in the suppression of macrophage functions by bile acids.
References in periodicals archive ?
Because GPCRs have specific roles in the regulation and modulation of brain circuit functions, these proteins are promising targets for drugs designed to relieve such symptoms.
Furthermore, where GPCRs showing disease associations have existing drug candidates in development for alternative indications we can rapidly identify opportunities to re-profile those molecules into treatment of this debilitating condition."
"This is an exciting development for Arena because it demonstrates that we are able to obtain patents on our core technologies that are broadly applicable to GPCRs. We believe that the ability to stabilize GPCRs in the active state and to reliably screen such GPCRs constitutes a robust discovery platform.
Confo Therapeutics' proprietary ConfoBodies are single domain antibodies uniquely derived to be selective and stabilize G-protein coupled receptors (GPCRs) in specific conformations, and as a result are valuable tools for drug discovery.
It can be used not only for GPCRs but for a lot of different biomolecules, explains Schihada.
We conclude that nephrin mRNA in peripheral blood measured by real-time gPCR is higher in females and in individuals with higher renal mass.
This tool is another example of why Cisbio Bioassays and HTRF have become synonymous with R&D innovation in the GPCR arena, as our portfolio enables researchers to investigate GPCRs from an increasing number of angles."
GE Healthcare Life Sciences also signed an exclusive agreement with DiscoveRX to distribute its HitHunter cAMP EFC (enzyme fragment complementation)-based assays for high-throughput GPCR screening, and also expanded its agreement for DiscoveRX's kinase assays to include exclusive distribution in Asia Pacific.
Specific topics include regulated releases of nucleotides and UDP sugars from astrocytoma cells, ectonucleotidases in the nervous system, ATP receptors of microglia involved in pain, and promoting neurotrophic effects by GPCR ligands.
Affitech generated new G protein-coupled receptor (GPCR) antibodies and will choose its first GPCR antibody drug candidate this year.
Given that olfactory receptors belong to the G-protein coupled receptor (GPCR) class of proteins-a family of molecules found in cell membranes throughout the body that are used by many commercial pharmaceuticals-Professor Ryan believes that his team's findings could also have applications to GPCR drug design also.