GPC1

GPC1

A gene on chromosome 2q35-q37 that encodes glypican 1, a cell surface proteoglycan with heparan sulfate that contains a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol (GPI) bond. The GPC family plays a role in controlling cell division and growth regulation.

Molecular pathology
Defects in processing glypican 1 occur in fibroblasts of patients with Niemann-Pick Type C1 disease.
References in periodicals archive ?
Glypican-1 (GPC1) is a proteoglycan that plays a role in the control of cell division and growth regulation.
GPC1 acts as a coreceptor for heparin-binding growth factor (HB-EGF) and fibroblast growth factor 2 (FGF-2) [75].
Table 11: Mix Designation Designation Mole GGBS(%) Fly ash Silica Steel (%) fume (%) fibre (%) GPC1 8 70 15 15 0 SFRGPC1 8 70 15 15 0.25 SFRGPC2 8 70 15 15 0.50 SFRGPC3 8 70 15 15 0.75 SFRGPC4 8 70 15 15 1.00 GPC2 12 70 15 15 0 SFRGPC5 12 70 15 15 0.25 SFRGPC6 12 70 15 15 0.50 SFRGPC7 12 70 15 15 0.75 SFRGPC8 12 70 15 15 1.00 GPC3 16 70 15 15 0 SFRGPC9 16 70 15 15 0.25 SFRGPC10 16 70 15 15 0.50 SFRGPC11 16 70 15 15 0.75 SFRGPC12 16 70 15 15 1.00 Table 12: Quantities Of Ingredients Used For Mix Proportions Particulars Quantity (kg/[m.sup.3]) GGBS 373 Flyash 80 Silica fume 80 Fine aggregate 504 Coarse aggregate 1176 NaOH 17 [Na.sub.2]Si[O.sub.3] 134 Water 36 4.1 Specimen Details:
GPC3 is a 60 kDa cell-surface protein that belongs to the heparan-sulfate proteoglycan family, which contains GPC1,2,3,4,5, and 6.
(17) Medicare policy incorporates only one-quarter of the geographic variation in physician labor costs into the physician work GPC1, effectively compensating physicians more generously in low-cost areas and less generously in high-cost areas.
From Figure 5, comparing PC1 and GPC1, in the presence of GAC, the lag phase for degradation was significantly lowered from 33 h to 6 h and consequently total degradation time decreased from 42 h to 12 h, or almost 4 times reduction in time taken.
Consequently, the total time needed for removal of phenol decreased from 42 h (PC1) to 12 h (GPC1) for the same phenol and 4-cp concentrations.