HSP90B1

(redirected from GP96)

HSP90B1

A gene on chromosome 12q24.2-q24.3 that encodes a molecular chaperone of the HSP 90 family which has ATPase activity and functions in the processing and transport of secreted proteins. HSP90B1 plays a role in endoplasmic reticulum associated degradation.
References in periodicals archive ?
We extracted mHSP/Ps, including HSP60, HSP70, GP96, and HSP110, from the mouse sarcoma cell lines S180 and MCA207 using chromatography.
GP96 is the most abundant member of HSP90 in the endoplasmic reticulum (ER), contains an N-terminal signal sequence (70 amino acid), characteristic of the ER-targeted proteins and a carboxyl terminal KDEL sequence (Lys-Asp-Glu-Leu), which is a retention/retrieval signal from the golgi to the ER.