GP6

GP6

A gene on chromosome 19q13.4 that encodes a 58-kD platelet membrane glycoprotein, which plays a central role in the collagen-induced platelet activation and aggregation. Injury to the vessel wall and damage to the endothelial lining exposes the subendothelial matrix to blood flow, resulting in deposition of platelets. Collagen, especially types I, III and VI, are the most thrombogenic macromolecules of the extracellular matrix. The adhesion of platelets to collagen results in activation, leading to platelet secretion, recruitment of additional platelets and aggregation resulting in a platelet plug, which limits blood loss. However, collagen exposure after rupture of atherosclerotic plaques results in thrombus formation and may lead to myocardial infarction or stroke.
References in periodicals archive ?
However, some polymorphisms of GP6 SNPs have been shown to be present more frequently in cases of SPS [19].
A previous study also investigated the epigenome-wide association of prenatal lead exposure with cord blood DNA methylation profiles in a birth cohort in rural Bangladesh (n = 127) with high environmental lead levels, and the authors identified a set of loci with FDR< 0.05, among which some were located around the gene glycoprotein VI (GP6) (Engstrom et al.
The first three of these policy proposals can be located in the context of generic policy six (GP6) which focuses on crime and the criminal justice system.
For methanogens, we used genomes of closely and distantly related species able to perform acetoclastic methanogenesis (A: Methanosaeta concilii GP6), methylotrophic methanogenesis (M-1: Methanococcoides burtonii DSM6242, M-2: Methanolobus tindarius DSM2278, and M3: Methanohalophilus mahii DSM5219), hydrogenotrophic methanogenesis (H-1: Methanospirillum hungatei JF-1, H-2: Methanobacterium formicicum DSM3637, H-3: Methanococcus maripaludis C5, and H-4: Methanoregula formicica SMSP), and both acetoclastic and methylotrophic methanogenesis (AM: Methanosarcina acetivorans C2A).
Snijders, "The use of general primers GP5 and GP6 elongated at their 3' ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR," Journal of General Virology, vol.
The following search terms were used: "platelet glycoprotein" or "GP I b-IX Complex" or "GP I b[alpha]" or "platelet membrane glycoprotein VI" or "HPA-2" or "GP I b[alpha]VNTR" or "GP6" AND "polymorphism or gene or variant or mutation" AND "coronary heart disease" or "CAD" or "myocardial infarction" or "angina" or "ischemic heart disease" or "ischemic cardiomyopathy" or "coronary artery stenosis".
To date, 17 genes have been robustly demonstrated to harbor genetic variations associated with VT risk: ABO, F2, F5, F9, F11, FGG, GP6, KNG1, PROC, PROCR, PROS1, SERPINC1, SLC44A2, STXBP5, THBD, TSPAN15, and VWF [25].
1: Selected indicators Name of indicator designation Completed dwellings per capita QL7-MP1 Real net disposable income per capita MP2 Average gross wage MP3 Unemployment rate MP4 Real GDP per capita MP5 Real gross value added per capita MP6 Real gross fixed capital formation per capita MP7-GP1 Number of businesses per capita GP2 Structure of employment GP3 Number of university students per capita GP4 Live births per capita GP5 Age structure GP6 Average incapacity for work due to sickness GP7-QL1 Environmental pollution QL2 Number of crimes per capita QL3 Number of cultural facilities for residents QL4 Number of physicians per capita QL5 Registered passenger cars per capita QL6 Source: [25] Tab.
The following classes were group Gp3 and then group Gp6, with 196 and 116 sequences, respectively.
The analysis of 16S rRNA gene clone libraries and pyrosequencing demonstrated that the abundance of Acidobacteria is usually correlated with low values of soil pH [22] and that subgroups GP1, GP4, and GP6 are predominant in soil [1, 23].
GENDER PRACTICE PREVIOUS YEAR GP1 Male 7 2 GP2 Male 3 3 GP3 Female 6 2 GP4 Female 1 1 GP5 Male 8 3 GP6 Male 18 1 GP7 Male 25 1 GP8 Male 20 4 Table 4: Sample quotes from the interviews by Theme 1--Characteristics of communication SUB-THEMES QUOTES FROM THE INTERVIEWS Primarily medical 'I think that I'm not sure how the dietitian officers communicate communicates currently with the GP or even if with GPs they do.