ITGB4

(redirected from GP150)

ITGB4

A gene on chromosome 17q25 that encodes an integrin beta chain protein (integrins are noncovalently associated transmembrane glycoprotein receptors, composed of alpha and beta chains). The beta chain encoded by ITGB4 usually associates with alpha 6, serving as a laminin receptor. It plays a key structural role in the hemidesmosomes, regulates keratinocyte polarity and motility and is a central player in the biology of invasive cancer.

Molecular pathology
ITGB4 mutations are associated with epidermolysis bullosa with pyloric atresia.
References in periodicals archive ?
Facey, "CD13 (GP150; aminopeptidase-N): predominant functional activity in blood is localized to plasma and is not cell-surface associated," Experimental Hematology, vol.
(20) The second plasmid expressed an HIV-1 subtype C truncated envelope protein (Env, gp150).
Human myeloid plasma membrane glycoprotein CD13 (gp150) is identical to aminopeptidase N.