GNB3


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GNB3

A gene on chromosome 12p13 that encodes a beta subunit of a heterotrimeric guanine nucleotide-binding protein (G protein), which regulates signal transduction between receptors and effectors.

Molecular pathology
A single-nucleotide polymorphism in GNB3 is associated with essential hypertension and obesity.
References in periodicals archive ?
Stepwise multiple linear regression analysis was performed to investigate the possible influence of GNB3 C825T polymorphism on posttreatment BP and BP response after adjustment for age, body mass index (BMI), heart rate (HR), baseline BP, gender (where 0 indicates female and 1 indicates male), the GNB3 C825T genotypes (where 0 indicates CC genotype, 1 indicates CT and 2 indicates TT).
The prevalence of GNB3 C825T genotype and allele frequencies were shown in [Table 2].
Significant difference in mean DBP and MAP levels among GNB3 C825T genotypes was observed after telmisartan therapy ( P = 0.001, P = 0.014, respectively) [Table 5], and patients carrying the 825TT ( n = 6) genotype showed significantly higher DBP and MAP than those carrying at least one 825C allele (CC + CT, n = 25, P = 0.009, P = 0.003, respectively), [Table 5].
According to the C825T polymorphism of the GNB3 gene, 45.7% of subjects were CC, 36.3% CT, and 18.0% TT.
Blood pressure or diagnosis of arterial hypertension, heart rate, body mass index or diagnosis of overweight, blood lipids or diagnosis of hypercholesterolaemia or hypertriglyceridaemia, blood glucose or diagnosis of diabetes, serum uric acid or diagnosis of hyperuricaemia, left ventricular mass index or diagnosis of left ventricular hypertrophy, history of cardiovascular disease, intake of ethanol or caffeine, and smoking did not influence either the response to the neuropsychological tests or their scores across the C825T polymorphism of GNB3 gene.
MMSE scored in average 26.1 [+ or -] 3.9 (CI 25.5-26.7) and was inversely related with age (r = -0.23, P < 0.0001) and not different across the C825T polymorphism of the GNB3 gene either before or after adjustment for age and education (Figure 1).
The frequency of occurrence of the D-allele ACE and C-allele GNB3 is higher among male patients with EH than control subjects.
"G-protein [beta]3 subunit gene (GNB3) variant in causation of essential hypertension," Hypertension, Vol.32, pp.1094-097.
The pathogenetic relevance of the C825T polymorphism relies on the fact that the 825T allele of GNB3 is related to enhanced stimulated G-protein activation in cell lines from hypertensive patients (16, 17).
They did not find an association between hypertension and GNB3 825T/C polymorphism.
The frequency of GNB3 825T allele was significantly higher in patients with non-typical vasovagal history than in group with typical history (p<0.001).
Conclusions: Genotype CC GNB3 is the most popular in vasovagal patients.