GNB3


Also found in: Acronyms.

GNB3

A gene on chromosome 12p13 that encodes a beta subunit of a heterotrimeric guanine nucleotide-binding protein (G protein), which regulates signal transduction between receptors and effectors.

Molecular pathology
A single-nucleotide polymorphism in GNB3 is associated with essential hypertension and obesity.
References in periodicals archive ?
Allele and genotype frequencies of the GNB3 gene Control Hypertension GNB3 genotypes groups group p (n=82) (n=209) CC, n (%) 27 (32.
A single nucleotide polymorphism C825T, located in exon 10, leads to an exchange at position 825 in the cDNA of the GNB3 the amino acid cytosine by thymidine (13), which causes the increased intracellular signal transduction and e.
All patients were genotyped for GNB3 C825T polymorphism and next analyzed in regard to typical vasovagal history.
The frequency of GNB3 825C allele was significantly higher in patients with typical vasovagal history than in patients with non-typical history and the manifestation of GNB3 825T allele prevailed in patients with non-typical history (p < 0.
In vasovagal patients, we found strong association between the GNB3 C825 allele and typical vasovagal history.