GNB2L1

GNB2L1

A gene on chromosome 5q35.3 that encodes a beta-polypeptide 2-like guanine nucleotide-binding protein (G protein) involved in recruiting, assembling and regulating various signalling molecules, interacting with various proteins and playing a role in multiple cell processes. It is involved in the recruitment, assembly and/or regulation of a variety of signalling molecules.
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We found epigenome-wide significant associations (FDR p < 0.05) between [PM.sub.10] exposure and DNA methylation for six CpGs, with higher [PM.sub.10] exposure being associated with an increase in methylation for four CpGs mapping to GNB2L1; SNORD96A, FAM13A, SRPRB, and P4HA2, and a decrease for two CpGs within USP4, and NOTCH4 (Table 2).
In addition, cgl5082635 (GNB2L1; SNORD96A) was also nominally significant in 7-to 9-y-olds from the ALSPAC study with the same direction of association (p = 0.02).
Our other observed differentially methylated CpGs reside in USP43, SRPRB, GNB2L1; SNORD96A, and a Th2 cytokine gene, P4HA2.
Also, significant differential methylation was observed for CpGs in FAM13A, GNB2L1, and SNORD96A, as well as P4HA2 in one out of three independent samples of school-age children, with the same direction of association as those in the discovery EWAS.
Delta (D)CT was calculated by using as housekeeping gene the average of CT values obtained for the genes 18S and GNB2L1. RQ was calculated using the [2.sup.-[DELTA][DELTA]CT] method [48].
For example, in 2015, Lee [33] and colleagues identified 8 human SNPs significantly associated with NSCLC prognosis, including CD3EAP rs967591, TNFRSF10B rs1047266, AKT1 rs3803300, C3 rs2287845, HOMER2 rs1256428, GNB2L1 rs3756585, ADAMTSL3 rs11259927, and CD3D rs3181259.