SUMO1

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SUMO1

A gene on chromosome 2q33 that encodes a ubiquitin-like protein, which can be covalently attached to proteins as a monomer or a lysine-linked polymer. This post-translational modification on lysine residues of protein (sumolyation) plays a crucial role in a number of cellular processes, including nuclear transport, DNA replication and repair, mitosis and signal transduction. SUMO1 may also regulate a network of genes involved in palate development. It interacts with CHD3, EXOSC9, HIF1A, HIPK2, HIPK3, PARK2, PIAS1, PIAS2,  RAD51, RAD52, RANBP2, SAE2, UBE2I and USP25.
 
Molecular pathology
Defects in SUMO1 cause non-syndromic orofacial cleft type 10.
References in periodicals archive ?
M2 EQUITYBITES-September 12, 2016-Thermo Fisher Scientific opens new state-of-the-art GMP1 standard facility in Seoul, South Korea
M2 PHARMA-September 12, 2016-Thermo Fisher Scientific opens new state-of-the-art GMP1 standard facility in Seoul, South Korea
- Bringing production facilities in line with Good Manufacturing Practice (GMP1 ) standards, which will become obligatory starting in 2014.