CSF2

(redirected from GMCSF)
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CSF2

A gene on chromosome 5q23-q31 that encodes colony stimulating factor 2 (granulocyte-macrophage), a cytokine that controls the production, differentiation and function of granulocytes and macrophages.

Molecular pathology
CSF2 is localised to a cluster of related genes at chromosome 5q31, a region associated with deletions in the 5q- syndrome and acute myelogenous leukaemia.
References in periodicals archive ?
Although a link between alcohol abuse and PAP has not been established, ethanol ingestion has been demonstrated to suppress GMCSF signalling and macrophage function in mice models.
It is also involved in enhancing the expression of MMPs and this was reversible by GMCSF blocking (Gutschalk et al.
Se ha demostrado tambien que la IL-1[beta] promueve la produccion de GMCSF en linfocitos T cd4+ y en linfocitos T[gamma][sigma] (Lukens et al., 2012), y estos se encuentran en grandes cantidades en la sangre de las alpacas, pudiendo ser un mecanismo de senalizacion secuencial en la regulacion de expresion de citocinas proinflamatorias en esta especie.
Melapuldencel-T - an irradiated autologous in vitro proliferating melanoma cell line loaded onto an autologous dendritic cell combined with granulocyte macrophage colony-stimulating factor (GMCSF) - has been approved to enter a Phase 3 clinical trial with Special Protocol Assessment (SPA) and received fast track designation for metastatic melanoma, as well as orphan drug designation.
For example, these cells express colony-stimulating factor (CSF), macrophage colony-stimulating factor (M-CSF), granulocyte-macrophage colony-stimulating factor (GMCSF), tumor necrosis factor alpha (TNF-[alpha]), interferon-[gamma] (IFN-[gamma]), and leukemia inhibitory (LIF) [33, 34].
CR3 expression is rapidly regulated by a number of stimulators such as granulocyte-macrophage colony-stimulating factor (GMCSF), formyl-methionyl-leucyl-phenylalanine, TNF-[alpha], and IL-10, and upregulation of CR3 expression is important in the migration of neutrophils through venules during inflammation [40].
reported that miR21* regulate the eosinophil apoptosis by enhancing GMCSF (expand) which activates and sustains the survival of eosinophils through ERK pathway.
Granted patents and pending applications in India for recombinant drugs Human insulin, Erythropoietin, Hepatitis B vaccine (recombinant surface antigen based), Human growth hormone, Interleukin 2, Interleukin 11, Granulocyte Colony Stimulating Factor (GCSF), Granulocyte Macrophage Colony Stimulating Factor (GMCSF), Interferon-2a, 2b and g, Streptokinase, Tissue Plasminogen Activator, Factor viii, Follicle stimulating hormone, Teriparatide (Forteo), Drotrecogin (Xigris) alpha, Platelet Derived Growth Factor (PDGF), Epidermal Growth factor (EGF) and Eptacogalpha (r-F VIIa) r-coagulation factor were identified.
It is known that tobacco smoke may affect the immune system in a variety of ways, including the expansion of auto-reactive B-lymphocytes and circulating T-lymphocytes and an increase in the production of pro-inflammatory cytokines such as interleukin 1, 6, 8, tumor necrosis factor [alpha] (TNF [alpha]), and granulocyte-macrophage colony stimulating factor (GMCSF).
nucleatum showed a significant cytokine/chemokine increase in GMCSF, Iterleukin-6 and Interleukin-8, which have the capacity to modulate HIV-1 promoter activation.