Although a link between alcohol abuse and PAP has not been established, ethanol ingestion has been demonstrated to suppress GMCSF
signalling and macrophage function in mice models.
has been used as an adjuvant in a variety of candidate vaccines [24, 25].
It is also involved in enhancing the expression of MMPs and this was reversible by GMCSF
blocking (Gutschalk et al.
Melapuldencel-T - an irradiated autologous in vitro proliferating melanoma cell line loaded onto an autologous dendritic cell combined with granulocyte macrophage colony-stimulating factor (GMCSF
) - has been approved to enter a Phase 3 clinical trial with Special Protocol Assessment (SPA) and received fast track designation for metastatic melanoma, as well as orphan drug designation.
in the treatment of a patient with severe methotrexate intoxication.
For example, these cells express colony-stimulating factor (CSF), macrophage colony-stimulating factor (M-CSF), granulocyte-macrophage colony-stimulating factor (GMCSF
), tumor necrosis factor alpha (TNF-[alpha]), interferon-[gamma] (IFN-[gamma]), and leukemia inhibitory (LIF) [33, 34].
CR3 expression is rapidly regulated by a number of stimulators such as granulocyte-macrophage colony-stimulating factor (GMCSF
), formyl-methionyl-leucyl-phenylalanine, TNF-[alpha], and IL-10, and upregulation of CR3 expression is important in the migration of neutrophils through venules during inflammation .
reported that miR21* regulate the eosinophil apoptosis by enhancing GMCSF
(expand) which activates and sustains the survival of eosinophils through ERK pathway.
Granted patents and pending applications in India for recombinant drugs Human insulin, Erythropoietin, Hepatitis B vaccine (recombinant surface antigen based), Human growth hormone, Interleukin 2, Interleukin 11, Granulocyte Colony Stimulating Factor (GCSF), Granulocyte Macrophage Colony Stimulating Factor (GMCSF
), Interferon-2a, 2b and g, Streptokinase, Tissue Plasminogen Activator, Factor viii, Follicle stimulating hormone, Teriparatide (Forteo), Drotrecogin (Xigris) alpha, Platelet Derived Growth Factor (PDGF), Epidermal Growth factor (EGF) and Eptacogalpha (r-F VIIa) r-coagulation factor were identified.
It is known that tobacco smoke may affect the immune system in a variety of ways, including the expansion of auto-reactive B-lymphocytes and circulating T-lymphocytes and an increase in the production of pro-inflammatory cytokines such as interleukin 1, 6, 8, tumor necrosis factor [alpha] (TNF [alpha]), and granulocyte-macrophage colony stimulating factor (GMCSF