SLC2A4

(redirected from GLUT-4)

SLC2A4

A gene on chromosome 17p13 that encodes insulin-responsive glucose transporter type 4, a plasma membrane that mediates facilitated glucose transport.

Molecular pathology
SLC2A4 mutations are associated with type-2 (non-insulin-dependent) diabetes.
References in periodicals archive ?
mRNA and protein expression of mitochondrial biogenesis-related genes - Peroxisome proliferator-activated receptor-a coactivator-1a (PGC-1a), energy balance key factor - adenosine monophosphate-activated protein kinase (AMPK), fatty acids oxidation factor - carnitine palmitoyltransferase-1 (CPT-1), and glucose oxidation factor - glucose transporter- 4 (GLUT-4) were measured by PCR and Western blotting analysis.
Carnitine palmitoyltransferase-1 (CPT-1) is thought to be the rate-limiting enzyme in FAO and is inhibited by malonyl-CoA.[7] Insulin-regulated glucose transporter-4 (GLUT-4) is immunolocalized in rat cardiac muscle under conditions of basal and stimulates glucose uptake, which are achieved by fasting and a combined exercise/insulin stimulus, respectively.[8] Mitochondrial dysfunction has been demonstrated to contribute to heart disease and its clinical manifestations, and damaged mitochondrial homeostasis might lead to heart failure over time.[9] Consequently, exploration of a new therapeutic strategy to improve mitochondrial function and energy metabolism may have great clinical significance.
Antibodies against GLUT-1 (ab652) and GLUT-4 (ab654) were purchased from LifeSpan BioSciences Inc.
OHC Uptake of 2-NBDG Is Modulated by GLUT-1 and GLUT-4 Antagonists.
In mature adipocytes, glucose transporter type 4 (Glut-4) is highly expressed and responds to insulin to lower blood glucose [10].
After the differentiation of 3T3-L1 preadipocytes was induced with a medium containing insulin, the cells undergo several rounds of mitosis referred to as mitotic clonal expansion at an early event of differentiation [15,16], A transcription factor, CCAAT/enhancer binding protein (C/EBP)-[beta], is required for the mitotic clonal expansion [15], After mitotic clonal expansion, the preadipocyte cells express the key transcription factor, PPAR[gamma], for adipocyte differentiation, which plays essential roles for inducing the adipocyte specific PPAR-[gamma] target genes such as Glut-4 and fatty acid binding protein [10], The 3T3-L1 cells gradually increase lipid droplet size and number during the differentiation process.
Liver, skeletal muscle and adipose tissue were also collected for mRNA gene expressions (GLUT-4, IRS-1, IR, PEPCK, SREBP-1c, FAS, PPAR-a, PPAR-g, TNF-a).
GBE showed up-regulation for hepatic IRS-1 and down-regulation for PEPCK, however, up-regulation for GLUT-4 and PPAR-a found in muscle.
(4,5) Studies have demonstrated isoforms of the SNAP-23, syntaxin-4 and VAMP-2 play important roles in regulating GLUT-4 traffic and vesicle fusion in adipocytes.
Key marker of diabetes in cells is the insulin dependent glucose transporter-4 (Glut-4) which also responds to exogenous chemicals, and is over expressed up to 5- and 4-fold, by Tinospora cord ifolia and palmatine, respectively.
Sessoes de treinamento de forca com duracao de 30 minutos, 3 vezes na semana, durante 6 semanas, aumentaram o conteudo proteico do GLUT-4, receptor de insulina, proteina [beta]-quinase, glicogenio sintetase e atividade total da glicogenio sintetase.
The purpose of the present study is to investigate the effect of methanolic extracts of Aegles marmelos and Syzygium cumini on a battery of targets glucose transporter (Glut-4), peroxisome proliferator activator receptor gamma (PPAR[gamma]) and phosphatidylinositol 3' kinase (PI3 kinase) involved in glucose transport.