GRIA4

(redirected from GLUR4)

GRIA4

A gene on chromosome 11q22 that encodes a member of the excitatory neurotransmitter glutamate receptor family, which are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) and function as ligand-activated cation channels.

Molecular pathology
Weak data have linked GRIA4 mutations to schizophrenia.
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References in periodicals archive ?
However, several unsuccessful genetic studies in humans have been developed to associate different SNPs in the AMPAR subunits, GluR1, GluR2, and GluR4 (encoded by the GRIA1, GRIA2, and GRIA4 genes, resp.), with SCZ [146], BPD [148], and major depressive disorder [149].
Abbomax has developed a panel of six anti-GluR antibodies: GluR1, GluR2/3, GluR4, GluR6/7, mGluR1, mGluR5.
GluRl is the most abundant subtype in laminae I and II where it overlaps with GluR2 and/or GluR3, while GluR4 is confined to some lamina I projection cells.
We examined the developmental expression of GluR subunits on embryonic days 10 through 20 (E10-E20) in the EW of chicks (Gallus gallus), We used antisera against GluR1 or GluR4, as well as an antiserum that was selective for, but did not distinguish between, GluR2 and GluR3 (GluR2/3).
We used antibodies against subunits GluR1, GluR4, and a third (GluR2/3), which recognizes a common epitope of the GluR2 and GluR3 subunits.
Antibodies used included those directed against AMPA receptor subunits GluR1 and GluR4, and one antibody that detects both GluR2 and GluR3 subunits.