Protein interacting with C kinase 1 (PICK1) and GluR2
are associated with presynaptic plasma membrane and vesicles in hippocampal excitatory synapses.
Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2
and NR2B glutamate receptor subunits in rat forebrain.
Aronica et al., "Global ischemia induces downregulation of glur2
mRNA and increases AMPA receptor-mediated [Ca.sup.2+] influx in hippocampal CA1 neurons of gerbil," The Journal of Neuroscience, vol.
Criteria to define DA neurons at day 70 were the following: neuronal morphology, coexpression of TH/ MAP2, coexpression of TH/dopamine transporter (DAT), coexpression of TH/vesicular monoamine-associated transporter 2 (VMAT2), coexpression of TH/AMPAR subunit GluR2
, and functional dopamine release and uptake from cultures containing DA neurons.
AMPA receptor calcium permeability is largely determined by the GluR2
subunit which is posttranscriptionally edited, changing a codon encoding glutamine to one encoding arginine (Gln/Arg) in the second transmembrane domain, making the receptor complex impermeable to calcium.
Gao et al., "Involvement of GluR2
upregulation in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptor in mice," Scientific Reports, vol.
Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2
ligand binding core.
However, the al-AR mediated LTD results from removal of GluRl subunits rather than GluR2
subunits from the AMPA receptors (McElligott et al.
High abundance of GluR1 mRNA and reduced Q/R editing of GluR2
mRNA in individual NADPH-diaphorase neurons.
They include reduced expression of kinases/phosphatases, cytoskeletal proteins, synaptic proteins, and neurotransmitter receptors in NFT-bearing CA1 neurons , downregulation of neurotrophic factors and upregulation of proapoptotic molecules in the hippocampal CA1 region , disturbed sphingolipid metabolism in various brain regions during progression of AD , and overexpression of the AMPA receptor GluR2
subunit in synaptosomes of the prefrontal cortex .
Zhu, "The early stage formation of PI3K-AMPAR GluR2
subunit complex facilitates the long term neuroprotection induced by propofol post-conditioning in rats," PLoS ONE, vol.
GluRl is the most abundant subtype in laminae I and II where it overlaps with GluR2
and/or GluR3, while GluR4 is confined to some lamina I projection cells.