Cocaine-induced behavioral sensitization in adolescent rats endures until adulthood: lack of association with GluR1
and NR1 glutamate receptor subunits and tyrosine hydroxylase.
Notably, Ras-GTP (a kinase in the ERK pathway) has been shown to induce trafficking of GluR1
to synapses , and GSK3[beta] promotes membrane localization of NMDA receptors .
Takahashi et al., "Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1
in synapses," Neurobiology of Disease, vol.
1 protein mediates reconsolidation of morphine CPP by increased GluR1
cell surface expression: activation of ERK-coupled CREB is required.
The role of nitric oxide and GluR1
in presynaptic and postsynaptic components of neocortical potentiation.
Reversal of cocaine-induced behavioral sensitization and associated phosphorylation of the NR2B and GluR1
subunits of the NMDA and AMPA receptors.
Sakai et al., "Nobiletin, a citrus flavonoid with neurotrophic action, augments protein kinase A-mediated phosphorylation of the AMPA receptor subunit, GluR1
, and the postsynaptic receptor response to glutamate in murine hippocampus," European Journal of Pharmacology, vol.
Possible role of platelet GluR1
receptors in comorbid depression and cardiovascular disease.
Topiramate reduces AMPA-induced Ca(2+) transients and inhibits GluR1
subunit phosphorylation in astrocytes from primary cultures.
In the same way, glutamate subunits GluR1
and NR1 are reduced, causing a profound deregulation in synapse-related proteins and behavior, marked deficits in social interaction behavior and an increased anxiety in the open field (Hermes, Li, Duman & Duman, 2011).
High abundance of GluR1
mRNA and reduced Q/R editing of GluR2 mRNA in individual NADPH-diaphorase neurons.
Abbomax has developed a panel of six anti-GluR antibodies: GluR1
, GluR2/3, GluR4, GluR6/7, mGluR1, mGluR5.