GLUL


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GLUL

An intronless gene on chromosome 1q31 that encodes a glutamine synthetase, which catalyses the synthesis of glutamine from glutamate and ammonia. Glutamine is a key source of energy and is involved in cell proliferation, inhibition of apoptosis, and cell signalling. GLUL is expressed during early foetal stages, and plays an important role in controlling pH by removing ammonia from circulation.

Molecular pathology
GLUL mutations are associated with congenital glutamine deficiency.
References in periodicals archive ?
In addition, here, we observed significant increase of GLUL expression in the livers and tumors of both PB-treated [Ogg1.sup.-/-] and [Ogg1.sup.+/+] animals.
Ten genes (SREBF1, DUSP1, PLAGL1, FKBP5, ZBTB16, PPP1R3C, CDC14A, GLUL, PDK4, and UCP3) were selected for validation by RT-PCR.
The genetic variant may affect CHD risk by reducing the expression of the GLUL gene which is involved in glutamine/glutamic acid metabolism.
A glicemia foi medida por metodo de referencia enzimatica com hexoquinase por kit comercial GLUL 0-991 (Roche[R], Basileia-Suica).
It has been reported that one of the important factors facilitating the interprotein communication is the carbodiimide crosslink formed by Glul 12 of NifH and Lys400 of NifK.
Glutamine synthetase is an enzyme that is involved in nitrogen metabolism and is upregulated in HA-B because of activation of GLUL, which is a [beta]-catenin target gene that codes for glutamine synthetase.