SLC1A2

(redirected from GLT1)

SLC1A2

A gene on chromosome 11p13-p12 that encodes solute carrier family 1 member 2, a high-affinity glutamate transporter that plays a key role in transporting glutamate across plasma membranes. In the brain, these transporters clear the excitatory neurotransmitter glutamate from the extracellular space at synapses in the CNS and maintain extracellular glutamate concentrations below neurotoxic levels.

Molecular biology
SLC1A2 mutations are associated with amyotrophic lateral sclerosis.
References in periodicals archive ?
Glutamate transporter GLT1 as a therapeutic target for substance use disorders.
N-acetylcysteine: A potential treatment for substance use disorders: This OTC antioxidant may benefit adults who use cocaine and adolescents who use marijuana
CEF was previously found to increase GLT1 expression, resulting in sequestration of excess synaptic glutamate and protection of hippocampal neurons from excitotoxicity [36].
Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies
As a result, they received a stable population of functional astrocytes, positive for S100B, GLT1, AlDOC, and CD44.
Adult Neural Stem Cells: Basic Research and Production Strategies for Neurorestorative Therapy
However, the overexpression of GLT1 via adenoviral vectors is not effective in reducing motor neuron death, supporting the multifaceted role of SOD1 in disease progression of ALS [128].
Oxidative Stress in Neurodegenerative Diseases: From Molecular Mechanisms to Clinical Applications
Third, decreased expression of glutamate transporter (GLT1) in glial cells after SCI causes hyperactivity of dorsal horn sensory neurons to lead to subsequent neuropathic pain.
Neuronal-Glial Interactions Maintain Chronic Neuropathic Pain after Spinal Cord Injury
While the activation of TNFR1 on astrocytes induces GDNF release protecting motor neurons, its activation also provokes a reduction in the glutamate transporter GLT1 causing an increase in extracellular glutamate with potential excitotoxic effects.
Amyotrophic Lateral Sclerosis, a Multisystem Pathology: Insights into the Role of TNF[alpha]
Spatial and Temporal Changes in Promoter Activity of the Astrocyte Glutamate Transporter GLT1 Following Traumatic Spinal Cord Injury.
Perspectives for the application of voltage-dependent calcium channels blockers conotoxin in spinal cord injury/ Perspectivas da aplicacao das conotoxinas bloqueadoras de canais para calcio dependentes de voltagem no trauma medular
434/[micro]g[L.sup.-1]; 2010 [5] IQ-UQ (136-1135) [micro]g[L.sup.-1] Amedjoe et 41 (39) /(glT1 al.
A systematic review of heavy metals of anthropogenic origin in environmental media and biota in the context of gold mining in ghana
A new study conducted by a team of Indiana University neuroscientists demonstrates that GLT1, a protein that clears glutamate from the brain, plays a critical role in the craving for cocaine that develops after only several days of cocaine use.
Brain protein to block cocaine craving identified
For the glial glutamate transporter GLT1, for example, all of the cotransported ions are coupled to each other as they cross the membrane (i.e., they are not independent).
Transport reversal during heteroexchange: a kinetic study
Role of Astrocyte Glutamate Transporter GLT1 in Secondary Loss After SCI
The quest countinues: more than $1 million in grants will help advance spinal-cord-injury research, as investigators search for a cure and better quality of life
Contralateral cortical response of a subpopulation of interneurons and the glial glutamate transporter GLT1 to an ischemic core
Respuesta de una subpoblacion de interneuronas y del transportador glial de glutamato GLT1 en la corteza contralateral a un foco isquemico
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