Glutamate transporter GLT1
as a therapeutic target for substance use disorders.
CEF was previously found to increase GLT1
expression, resulting in sequestration of excess synaptic glutamate and protection of hippocampal neurons from excitotoxicity .
As a result, they received a stable population of functional astrocytes, positive for S100B, GLT1
, AlDOC, and CD44.
However, the overexpression of GLT1
via adenoviral vectors is not effective in reducing motor neuron death, supporting the multifaceted role of SOD1 in disease progression of ALS .
Third, decreased expression of glutamate transporter (GLT1
) in glial cells after SCI causes hyperactivity of dorsal horn sensory neurons to lead to subsequent neuropathic pain.
While the activation of TNFR1 on astrocytes induces GDNF release protecting motor neurons, its activation also provokes a reduction in the glutamate transporter GLT1
causing an increase in extracellular glutamate with potential excitotoxic effects.
Spatial and Temporal Changes in Promoter Activity of the Astrocyte Glutamate Transporter GLT1
Following Traumatic Spinal Cord Injury.
434/[micro]g[L.sup.-1]; 2010  IQ-UQ (136-1135) [micro]g[L.sup.-1] Amedjoe et 41 (39) /(glT1
A new study conducted by a team of Indiana University neuroscientists demonstrates that GLT1
, a protein that clears glutamate from the brain, plays a critical role in the craving for cocaine that develops after only several days of cocaine use.
For the glial glutamate transporter GLT1
, for example, all of the cotransported ions are coupled to each other as they cross the membrane (i.e., they are not independent).
Role of Astrocyte Glutamate Transporter GLT1
in Secondary Loss After SCI
Contralateral cortical response of a subpopulation of interneurons and the glial glutamate transporter GLT1
to an ischemic core