SLC1A2

(redirected from GLT1)

SLC1A2

A gene on chromosome 11p13-p12 that encodes solute carrier family 1 member 2, a high-affinity glutamate transporter that plays a key role in transporting glutamate across plasma membranes. In the brain, these transporters clear the excitatory neurotransmitter glutamate from the extracellular space at synapses in the CNS and maintain extracellular glutamate concentrations below neurotoxic levels.

Molecular biology
SLC1A2 mutations are associated with amyotrophic lateral sclerosis.
References in periodicals archive ?
CEF was previously found to increase GLT1 expression, resulting in sequestration of excess synaptic glutamate and protection of hippocampal neurons from excitotoxicity [36].
As a result, they received a stable population of functional astrocytes, positive for S100B, GLT1, AlDOC, and CD44.
However, the overexpression of GLT1 via adenoviral vectors is not effective in reducing motor neuron death, supporting the multifaceted role of SOD1 in disease progression of ALS [128].
Third, decreased expression of glutamate transporter (GLT1) in glial cells after SCI causes hyperactivity of dorsal horn sensory neurons to lead to subsequent neuropathic pain.
While the activation of TNFR1 on astrocytes induces GDNF release protecting motor neurons, its activation also provokes a reduction in the glutamate transporter GLT1 causing an increase in extracellular glutamate with potential excitotoxic effects.
434/[micro]g[L.sup.-1]; 2010 [5] IQ-UQ (136-1135) [micro]g[L.sup.-1] Amedjoe et 41 (39) /(glT1 al.
A new study conducted by a team of Indiana University neuroscientists demonstrates that GLT1, a protein that clears glutamate from the brain, plays a critical role in the craving for cocaine that develops after only several days of cocaine use.
For the glial glutamate transporter GLT1, for example, all of the cotransported ions are coupled to each other as they cross the membrane (i.e., they are not independent).
Contralateral cortical response of a subpopulation of interneurons and the glial glutamate transporter GLT1 to an ischemic core