Glutamate transporter
GLT1 as a therapeutic target for substance use disorders.
CEF was previously found to increase
GLT1 expression, resulting in sequestration of excess synaptic glutamate and protection of hippocampal neurons from excitotoxicity [36].
As a result, they received a stable population of functional astrocytes, positive for S100B,
GLT1, AlDOC, and CD44.
However, the overexpression of
GLT1 via adenoviral vectors is not effective in reducing motor neuron death, supporting the multifaceted role of SOD1 in disease progression of ALS [128].
Third, decreased expression of glutamate transporter (
GLT1) in glial cells after SCI causes hyperactivity of dorsal horn sensory neurons to lead to subsequent neuropathic pain.
While the activation of TNFR1 on astrocytes induces GDNF release protecting motor neurons, its activation also provokes a reduction in the glutamate transporter
GLT1 causing an increase in extracellular glutamate with potential excitotoxic effects.
Spatial and Temporal Changes in Promoter Activity of the Astrocyte Glutamate Transporter
GLT1 Following Traumatic Spinal Cord Injury.
434/[micro]g[L.sup.-1]; 2010 [5] IQ-UQ (136-1135) [micro]g[L.sup.-1] Amedjoe et 41 (39) /(
glT1 al.
A new study conducted by a team of Indiana University neuroscientists demonstrates that
GLT1, a protein that clears glutamate from the brain, plays a critical role in the craving for cocaine that develops after only several days of cocaine use.
For the glial glutamate transporter
GLT1, for example, all of the cotransported ions are coupled to each other as they cross the membrane (i.e., they are not independent).
Role of Astrocyte Glutamate Transporter
GLT1 in Secondary Loss After SCI
Contralateral cortical response of a subpopulation of interneurons and the glial glutamate transporter
GLT1 to an ischemic core