SLC1A2

(redirected from GLT-1)

SLC1A2

A gene on chromosome 11p13-p12 that encodes solute carrier family 1 member 2, a high-affinity glutamate transporter that plays a key role in transporting glutamate across plasma membranes. In the brain, these transporters clear the excitatory neurotransmitter glutamate from the extracellular space at synapses in the CNS and maintain extracellular glutamate concentrations below neurotoxic levels.

Molecular biology
SLC1A2 mutations are associated with amyotrophic lateral sclerosis.
References in periodicals archive ?
Among other commonalities, both cell types produce the protein GLT-1, the mammalian version of which is responsible for clearing the chemical glutamate away from synapses.
elegans lacking GLT-1. Surprisingly, this depletion did not result in glutamate accumulation at synapses, as was expected.
But worms lacking GLT-1, the researchers found, took this action to the extreme: at 90 second intervals the animals executed not one reversal, but bursts of them.
Carnosine decreased the glutamate levels and preserved the expression of glutamate transporter-1 (GLT-1) but not the glutamate/aspartate transporter in astrocytes exposed to ischemia in vivo and in vitro.