GLI2


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Related to GLI2: Gli3

GLI2

A gene on chromosome 2q14 that encodes a protein belonging to the C2H2-type zinc finger protein subclass of the Gli family of transcription activators, which mediate Sonic hedgehog (Shh) signalling. GLI2 localises to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression, and may play a role in embryogenesis.

Molecular pathology
GLI2 mutations have been linked to Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, pre-axial polydactyly type IV and postaxial polydactyly types A1 and B.
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EZN-4482 and EZN-4496 were demonstrated to silence GLI2 expression with or without transfection in vitro.
The LNA based GLI2 antagonists potently and specifically inhibited GLI2 mRNA expression and tumor growth in two tumor models.
Specific silence of GLI2 expression EZN-4482 in vivo can lead to inactivation of Hh signaling pathway as indicated by down-modulation of GLI1 and Ptch1 expression
Nasdaq: ENZN) today announced new data will be presented on Locked Nucleic Acid (LNA) based antisense oligonucleotide programs directed against, the androgen receptor (AR), hedgehog pathway GLI2, and beta-catenin.
LNA (Locked nucleic acid) oligonucleotide based Gli2 RNA antagonist, EZN-4482, effectively inhibited tumor growth and increased survivin of animals with liver metastasis (Abstract C146)
Emerging evidence suggests that Gli1 and Gli2 represent the main activators of the Hedgehog (Hh) pathway due to amplification, overexpression of the Hh ligand, and mutations of components along the Hh pathway.
We are also excited to present preclinical data from our locked-nucleic acid (LNA) targets, the androgen receptor, b-catenin and GLI2 antagonists.