GLI2


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Related to GLI2: Gli3

GLI2

A gene on chromosome 2q14 that encodes a protein belonging to the C2H2-type zinc finger protein subclass of the Gli family of transcription activators, which mediate Sonic hedgehog (Shh) signalling. GLI2 localises to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression, and may play a role in embryogenesis.

Molecular pathology
GLI2 mutations have been linked to Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, pre-axial polydactyly type IV and postaxial polydactyly types A1 and B.
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In contrast, the expression of MSX1 , GLI2 , and IRF6 was significantly upregulated in NSCL as compared with healthy tissues.
Genome-Wide Screening of Aberrant Methylation Loci for Nonsyndromic Cleft Lip
Other candidate genes are involved in the physiology of growth, such as GLI2 in myogenesis and osteoblast differentiation [31], NYAP2 in brain size, neurite elongation and neuronal morphogenesis [32], and ZFPM2 in adipogenesis [33].
Identification of growth trait related genes in a Yorkshire purebred pig population by genome-wide association studies
Beachy, "Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector," Proceedings of the National Acadamy of Sciences of the United States of America, vol.
Apoptotic Signaling Pathways in Glioblastoma and Therapeutic Implications
Whetstone et al., "Gli2 and p53 cooperate to regulate IGFBP-3-mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors," Cancer Cell, vol.
Aberrant hedgehog signaling and clinical outcome in osteosarcoma
Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephalylike features.
Profile of skills of development in children with holoprosencephaly and holoprosencephaly-like/Perfil de habilidades do desenvolvimento em criancas com Holoprosencefalia e Holoprosencefalia like
Vanderbilt University researchers found TGF-[beta]1 increases parathyroid hormone-related protein (PTHrP) activity by stimulating the Gli2 signaling molecule, speeding bone loss.
A new paradigm for bone health: there's a new sheriff in town, along with a new role for nutraceuticals
Analysis showed that darinaparsin reduced the levels of the transcription factor Gli2, a downstream effector of the activated Hedgehog pathway which is elevated in certain cancers.
Ziopharm unveils results of darinaparsin studies in prostate cancer
Specifically, the researchers found that arsenic trioxide blocks the ability of a protein called Gli2 to induce gene transcription in the nucleus.
Arsenic could be a potential cancer treatment
Asimismo, se han encontrado mutaciones en 9 genes como causantes de HPE: SHH, PTCH, GLI2, DHCR7, ZIC2, TDGF1, TGIF, FAST1 y SIX3.
Vigilancia epidemiologica de ciclopia en el Hospital Universitario del Valle, Cali (Colombia) 2004-2008
The transcription factor Gli2 plays a key role within this pathway, indeed, Gli2 is responsible for the marked apoptosis resistance of the BCCs.
Apoptosis and pathogenesis of melanoma and nonmelanoma skin cancer
Another protein stabilized by proteasome inhibitor is Gli2, which promotes bone formation through upregulating bone morphogenetic protein-2 (BMP2) [29, 30].
Deubiquitinating Enzymes and Bone Remodeling
Tras la union al receptor PTCH1 en las celulas intersticiales fetales, DHH induce respuestas intracelulares por medio de factores de transcripcion GLI1 y GLI2 (Szczepny et al., 2006; Sahin et al., 2014).
Epithelial-Mesenchymal Transitions in the Development of Testis/Interacciones Epitelio-Mesenquimaticas en el Desarrollo Testicular

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