GLI2


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Related to GLI2: Gli3

GLI2

A gene on chromosome 2q14 that encodes a protein belonging to the C2H2-type zinc finger protein subclass of the Gli family of transcription activators, which mediate Sonic hedgehog (Shh) signalling. GLI2 localises to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression, and may play a role in embryogenesis.

Molecular pathology
GLI2 mutations have been linked to Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, pre-axial polydactyly type IV and postaxial polydactyly types A1 and B.
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The hedgehog regulated oncogenes Gli1 and Gli2 block myoblast differentiation by inhibiting MyoD-mediated transcriptional activation.
Western analysis showed that darinaparsin decreased levels of the transcription factor Gli2, a downstream effector of the activated Hedgehog pathway which is elevated in certain cancers.
The activity of Shh signaling pathway in targeting gene expression is controlled by the Gli family (Gli1, Gli2, and Gli3), which is primarily regulated by GSK-3 [10].
The activity of the Shh signaling pathway targeting genes expression is controlled by the Gli family (Gli1, Gli2, and Gli3).
EZN-4482 and EZN-4496 are two LNA-based GLI2 mRNA antagonists.
EZN-4482 and EZN-4496 were demonstrated to silence GLI2 expression with or without transfection in vitro.
55,74,75) Group 2 tumors are associated with numerous cytogenetic abnormalities that may include changes at regions encompassing SHH-related genes such as PTCH1, GLI2, NOTCH1, SMO, and SUFU.
Nasdaq: ENZN) today announced new data will be presented on Locked Nucleic Acid (LNA) based antisense oligonucleotide programs directed against, the androgen receptor (AR), hedgehog pathway GLI2, and beta-catenin.
Upon activation of HH signaling by binding of 1 of the 3 mammalian HH proteins (sonic hedgehog, Indian hedgehog, desert hedgehog) to PTCH, SMO is released and then activates interacting proteins such as suppressor of fused (SUFU), ultimately leading to activation of Gli (Gli family zinc finger) transcription factors Glil, Gli2, and Gli3, whose function is controlled by phosphorylation and proteolytic degradation (Figure 2).
Regarding the downstream consequences of upregulated HH signaling, Gli2 has been shown to induce G1-S cell cycle progression.
LNA (Locked nucleic acid) oligonucleotide based Gli2 RNA antagonist, EZN-4482, effectively inhibited tumor growth and increased survivin of animals with liver metastasis (Abstract C146)
We are also excited to present preclinical data from our locked-nucleic acid (LNA) targets, the androgen receptor, b-catenin and GLI2 antagonists.