In contrast, the expression of MSX1 , GLI2
, and IRF6 was significantly upregulated in NSCL as compared with healthy tissues.
Other candidate genes are involved in the physiology of growth, such as GLI2
in myogenesis and osteoblast differentiation , NYAP2 in brain size, neurite elongation and neuronal morphogenesis , and ZFPM2 in adipogenesis .
Beachy, "Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2
transcriptional effector," Proceedings of the National Acadamy of Sciences of the United States of America, vol.
Whetstone et al., "Gli2
and p53 cooperate to regulate IGFBP-3-mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors," Cancer Cell, vol.
Loss-of-function mutations in the human GLI2
gene are associated with pituitary anomalies and holoprosencephalylike features.
Vanderbilt University researchers found TGF-[beta]1 increases parathyroid hormone-related protein (PTHrP) activity by stimulating the Gli2
signaling molecule, speeding bone loss.
Analysis showed that darinaparsin reduced the levels of the transcription factor Gli2
, a downstream effector of the activated Hedgehog pathway which is elevated in certain cancers.
Specifically, the researchers found that arsenic trioxide blocks the ability of a protein called Gli2
to induce gene transcription in the nucleus.
The transcription factor Gli2
plays a key role within this pathway, indeed, Gli2
is responsible for the marked apoptosis resistance of the BCCs.
Another protein stabilized by proteasome inhibitor is Gli2
, which promotes bone formation through upregulating bone morphogenetic protein-2 (BMP2) [29, 30].
Tras la union al receptor PTCH1 en las celulas intersticiales fetales, DHH induce respuestas intracelulares por medio de factores de transcripcion GLI1 y GLI2
(Szczepny et al., 2006; Sahin et al., 2014).