GLI2


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Related to GLI2: Gli3

GLI2

A gene on chromosome 2q14 that encodes a protein belonging to the C2H2-type zinc finger protein subclass of the Gli family of transcription activators, which mediate Sonic hedgehog (Shh) signalling. GLI2 localises to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression, and may play a role in embryogenesis.

Molecular pathology
GLI2 mutations have been linked to Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, pre-axial polydactyly type IV and postaxial polydactyly types A1 and B.
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In contrast, the expression of MSX1 , GLI2 , and IRF6 was significantly upregulated in NSCL as compared with healthy tissues.
Other candidate genes are involved in the physiology of growth, such as GLI2 in myogenesis and osteoblast differentiation [31], NYAP2 in brain size, neurite elongation and neuronal morphogenesis [32], and ZFPM2 in adipogenesis [33].
Beachy, "Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector," Proceedings of the National Acadamy of Sciences of the United States of America, vol.
Whetstone et al., "Gli2 and p53 cooperate to regulate IGFBP-3-mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors," Cancer Cell, vol.
Vanderbilt University researchers found TGF-[beta]1 increases parathyroid hormone-related protein (PTHrP) activity by stimulating the Gli2 signaling molecule, speeding bone loss.
Analysis showed that darinaparsin reduced the levels of the transcription factor Gli2, a downstream effector of the activated Hedgehog pathway which is elevated in certain cancers.
Specifically, the researchers found that arsenic trioxide blocks the ability of a protein called Gli2 to induce gene transcription in the nucleus.
Asimismo, se han encontrado mutaciones en 9 genes como causantes de HPE: SHH, PTCH, GLI2, DHCR7, ZIC2, TDGF1, TGIF, FAST1 y SIX3.
The transcription factor Gli2 plays a key role within this pathway, indeed, Gli2 is responsible for the marked apoptosis resistance of the BCCs.
Another protein stabilized by proteasome inhibitor is Gli2, which promotes bone formation through upregulating bone morphogenetic protein-2 (BMP2) [29, 30].
Tras la union al receptor PTCH1 en las celulas intersticiales fetales, DHH induce respuestas intracelulares por medio de factores de transcripcion GLI1 y GLI2 (Szczepny et al., 2006; Sahin et al., 2014).