KLF4

(redirected from GKLF)

KLF4

A gene on chromosome 9q31 that encodes a protein of the Krüppel-like family of transcription factors that can act as an activator and repressor. KLF4 binds to its own promoter region and activates self-transcription; it regulates expression of key transcription factors during embryonic development and plays an important role in keeping embryonic stem cells in stasis, preventing their differentiation. KLF4 is required for the barrier function of the skin and the ocular surface. It is involved in epithelial cell differentiation and may play a role in skeletal and kidney development. KLF4 contributes to downregulating p53/TP53 transcription.
References in periodicals archive ?
Kruppel-like factor 4 (KLF4) can also be referred to as gut-enriched KLF (GKLF) or epithelial zinc finger protein (EZF) which mainly expresses in epithelial tissues of the mammals, including the intestine, skin, thymus, and lung.
Search terms represented as follows: (KLF4 OR Kruppel-like factor 4 OR Gut-enriched KLF OR GKLF OR ZEF OR Epithelial Zinc Finger Protein) AND (cancer OR tumor OR neoplasm OR carcinoma) AND (Prognosis OR prognostic OR survival OR outcome).
However, the cell proliferation was inhibited when cells are treated with [H.sub.2][O.sub.2], where the transcription factor gut-enriched Kruppel-like factor (GKLF) is induced.
Muller et al., "Redox-sensitive vascular smooth muscle cell proliferation is mediated by GKLF and Id3 in vitro and in vivo," The FASEB Journal, vol.
(10) The gut-enriched Kriippel-like factor (GKLF, KLF4) is a transcription factor with a high level of expression in gastrointestinal epithelial cells, the skin, and the thymus.
Search terms represented as follows: (KLF4 OR Kruppel-like factor 4 OR Gutenriched KLF OR GKLF OR ZEF OR Epithelial Zinc Finger Protein) AND (cancer OR tumor OR neoplasm OR carcinoma) AND (Prognosis OR prognostic OR survival OR outcome).