Jason Yang noted: 'Early symptoms of GIST
are relatively unpronounced; as a result, some GIST
patients are undiagnosed until advanced stages.
mutations in exons 12, 14 and 18, including the exon 18 D842V mutation, involved in a subset of GIST
- The majority of the industry-sponsored drugs in active clinical development for GIST
are in Phase II.
The fact that the genotype of each GIST
influences the treatment response, drug resistance, and prognosis, accurate diagnosis is essential for adequate and prompt treatment.
Apoptosis of GIST
cells was detected using annexin V-FITC Apoptosis Detection kit (Abcam, USA) according to the manufacturer's protocol.
Gastrointestinal Stromal Tumors (GIST
): a prospective analysis and an update on biomarkers and current treatment concepts.
Global epidemiology of gastrointestinal stromal tumours (GIST
): A systematic review of population-based cohort studies.
In certain reports, rectal GIST
is classified into two risk groups where low-risk group refers to tumors smaller than 5 cm and exhibiting fewer than 5 mitoses per 50 HPF and the high-risk group includes patients with tumors of 5 cm and more or exhibiting more than 5 mitoses per 50 HPF or both., Hohenberger and Eisenberg additionally concluded that low-risk GIST
may not benefit from adjuvant treatment if resected with clear margins; however, for high-risk lesions, adjuvant therapy must be considered.
ORs and associated 95% CIs were used to assess the treatment efficacy of sunitinib in imatinib-resistant or imatinib-intolerant GIST
patients with different genotypes.
Most case reports present cases of diagnosed GIST
with subsequent development of Desmoid tumor.
Based on tumor size and mitotic activity, possibility of a malignant GIST
was suggested along with immunohistochemical analysis (CD117 and CD34) for further confirmation.