The diagnosis is triggered by GI bleeding
, incidental findings during surgery or imaging and, in rare cases, tumour rupture or GI obstruction.
The researchers tallied rates of all-cause death, ischemic stroke, intracranial hemorrhage, hospitalization for GI bleeding
, hospitalization for major bleeding, and the composite of these outcomes at follow-up.
Negligence of prescribing PPIs for patients in the high-risk group for NSAIDs-related GI bleeding
is on one hand, whereas the inappropriate use of PPIs is on the other (1-4).
"If an individual has any abrasions in the GI tract or unbeknown to him has a peptic ulcer, taking a paracetamol without any pain, can irritate the lining of the stomach and aggravate an ulcer resulting in GI bleeding
Data Extraction: Study characteristics including year of publication, the first author, country, study design, sample size, type of endoscopic treatment, mean age, concomitant diseases, and location of GI bleeding
were extracted from eligible studies.
The recently published International Consensus Recommendations on the management of patients with non-variceal upper GI bleeding
recommend "early risk stratification", by using validated prognostic scales.
In a 30-patient pilot trial, Mesoblast's allogenic mesenchymal precursor cell (MPC) therapy Revascor showed a 70 percent reduction in GI bleeding
Under the RMAT designation, Mesoblast received specific guidance from the FDA that reduction in major GI bleeding
episodes and related hospitalizations in the current trial is a clinically meaningful outcome with a high unmet need that could meet requirements for an approvable regulatory endpoint.
Various malignancies with metastasis to the small intestine present as GI bleeding
, which includes GI stromal tumor, intestinal lymphangiomas, Kaposi's sarcoma, melanoma, and breast cancer.
Aortoenteric fistula (AEF) is one of the rare causes of GI bleeding
that can be fatal if not diagnosed and treated promptly.
Patients with a history of GI bleeding
or stomach problems with traditional NSAIDs should use celecoxib.
The most conservative comparison yielded an NNH of 72 over 10 years of therapy (1.39 excess major GI bleeding
events per 1000 person-years, 95% Cl, 0.70-2.28).