GHR

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GHR

A gene on chromosome 5p13-p12 that encodes growth hormone receptor, a type-I cytokine receptor which, once GH is bound, dimerizes and activates the JAK2/STAT5 transduction pathway, leading to growth.

Molecular pathology
Defects in GHR cause Laron type dwarfism.
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References in periodicals archive ?
To conduct a detailed study of the influence of GH signalling on AgRP neurons, the scientists bred genetically modified mice with AgRP-specific GH receptor ablation (called AgRP GHR knockout mice).
Growth hormone acts to foil weight loss: Study
He then talked about dopamine agonist's therapy, GH Receptor agonists, medical treatment of prolactinomas and Cushing's syndrome.
Aggressive treatment of diabetes, early initiation of Insulin will reduce treatment cost and complications - Prof. A.H. Aamir
identified a new longevity-associated allele consisting of a splice isoform of the GH receptor (GHR) lacking exon 3 (d3-GHR).
New Clues to Human Longevity
In mice with liver GH receptor (GH-R) knockout, metabolic syndrome (MetS), steatohepatitis, increased inflammation, liver fibrosis, and hepatic tumor develop [4].
Type 2 Diabetes Mellitus, a Sequel of Untreated Childhood Onset Growth Hormone Deficiency Developing in a 17-Year-Old Patient
It is caused by homozygous mutation of the GH receptor (GHR) gene; the literature describes about 300-500 patients with different mutations [5-7].
Same Phenotype in Children with Growth Hormone Deficiency and Resistance
Indeed, stimulated JAK2 adds a phosphate group to specific tyrosine residues on the cytoplasmic domain of the GH receptor. Therefore, using its Src homology 2 (SH2) domain, STAT5 binds to these phosphorylated tyrosine residues [84].
Gender in Endocrine Diseases: Role of Sex Gonadal Hormones
It has also been demonstrated that androgens can increase periosteal bone growth even in the absence of the GH receptor and with no increase in IGF-I.
Age and Developmental Stage Dependent Changes in Plasma Concentrations of Growth Hormone and Testosterone and Linear Growth Velocity in Boys between the Age of 1 and 20 Years
For production of circulatory IGF 1, actions of GH are started by its binding to GH receptor (GHR) on the surface of liver cells [9].
Astragalus Extract Mixture HT042 Increases Longitudinal Bone Growth Rate by Upregulating Circulatory IGF-1 in Rats
However, the effect of GH therapy on the final height is substantially variable depending on several clinical and genetic factors such as polymorphisms related with GH receptor and/or IGFBP3 gene, young age, and bone age delay at the start of GH treatment.
A Critical Appraisal of Growth Hormone Therapy in Growth Hormone Deficiency and Turner Syndrome Patients in Turkey
Fewer DNA breaks and increased apoptosis were found in cell cultures exposed to oxidant agents added with serum obtained from subjects with GH receptor deficiency [128].
Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats
After GH binding to growth hormone receptor (GHR), tyrosine kinase janus kinase 2 (JAK2) is activated, which in turn phosphorylates multiple tyrosines within both itself and the GH receptor, as well as multiple signalling pathways.
Development and characterization of a novel anti-idiotypic monoclonal antibody to growth hormone, which can mimic physiological functions of growth hormone in primary porcine hepatocytes
Additionally, increased affinity of GH binding proteins (GHBP) and GH receptor desensitization further displays the complexity of the hypothalamic-pituitary axis.
Acute exercise-induced growth hormone is attenuated in response to short-term, high-intensity exercise training

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