GFRA1


Also found in: Acronyms.

GFRA1

A gene on chromosome 10q26.11, that encodes a glial cell line-derived neurotrophic factor, which is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and neurturin, and mediates activation of the RET tyrosine kinase receptor.

Molecular pathology
GFRA1 mutations have been tentatively linked to Hirschsprung disease.
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References in periodicals archive ?
Despite this, we showed that the expression especially of NGF, NGFR, NTRK1, GFRA1, GFAP, and GDNF was upregulated in patients with severe neuropathy as compared to healthy subjects and diabetic patients with subclinical neuropathy.
NGF: nerve growth factor, NGFR: NGF receptor, NTRK1: neurotrophic receptor tyrosine kinase 1, GDNF: glial cell-derived neurotrophic factor, GFRA1: GDNF family receptor alpha 1, GFAP: glial fibrillary acidic protein.
The variations in the expression of 17 genes (underlined in Table 2) are involved in specific neuronal pathways, such as neuronal cell structure (GPM6B, PRPH, RELN), neural signaling and development (HOXB2, ELAVLI, EFNB1, NRG2, NELL1, MDK, GFRA1), synaptogenesis and steroid biosynthesis (SYCP2, PCDH17, STX1B2, SCG5, Nstage 4 diseasel, GATA3, NROB1).