MSTN

(redirected from GDF8)
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MSTN

A gene on chromosome 2q32.2 that encodes myostatin, a member of the bone morphogenetic protein family, which regulates cell growth and differentiation in both embryonic and adult bone and cartilage. Myostatin appears to downregulate skeletal muscle growth.
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This role of GDF11 as negative autoregulation of cell proliferation is in accordance with the negative role of GDF8 as muscle cell proliferation regulation [9].
GDF11 has more than 90% sequence identity with GDF8. Other members of TGF-[beta] superfamily have also high sequence identities.
cuniculus and nine different mammals, ten sequences each of GDF8, inhibin and BMP7 of same animals were also retrieved from GenPept for phylogenetic systematics.
BLASTp was used to identify local regions of similarity and statistical significance of GDF11, GDF8, inhibin and BMP7 protein sequences from ten selected organisms including O.
Evidence for multiple alleles effecting muscling and fatness at the Ovine GDF8 Locus.