KAT2A

(redirected from GCN5)

KAT2A

A gene on chromosome 17q12-q21 that encodes a ubiquitously expressed histone acetyltransferase, which acts primarily as a transcriptional activator. KAT2A also downregulates NF-kappB by promoting ubiquitination of the NF-kappB subunit RELA in a HAT-independent manner. It is recruited by HIV-1’s viral Tat protein, regulates Tat's transactivating activity, and may help induce chromatin remodelling of proviral genes.
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References in periodicals archive ?
In a similar sex-specific manner, arsenic exposure increased H3K9ac and the histone acetyltransferase GCN5 in the DG, whereas H3K9ac (KE7) and GCN5 (KE8) were decreased in the FC of male mice.
reesei, acetyltransferases belonging to the GCN5 family are crucial for cellulase expression [89].
Epigenetic Disease marks Alteration Reference Neural tube Histone (i) Myelomeningocele [78] defects (a) High levels of H3K4me2, H3K4me3, H3K27me2, and H3K27me3; (b) Low levels of KDM6B; (c) Decreased levels of H3K9ac, H3K18ac, and Gcn5. (ii) Anencephalic (a) increased levels of H3K27me3, H3K9Ac, H3K18Ac, and Gcn5.
The N-terminal domain of Myc forms complexes with transcriptional factors including TRRAP, GCN5 and TBP (Liu et al., 2003).
Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5. J Endocrinol.
HATs contain a bromodomain that recognizes and binds to histone acetylation, and they are categorized into three major families, GNAT (GCN5 and PCAF), MYST (Tip60 and MOF), and CBP/p300.
Mai, "Epigenetic modulation of PGC-1[alpha] activity by GCN5 inhibitors: W02010007085," Expert Opinion on Therapeutic Patents, vol.
Puigserver, "GCN5 acetyltransferase complex controls glucose metabolism through transcriptional repression of PGC1-[alpha]," Cell Metabolism, vol.
Based on sequence conservation within the HAT domain and substrate (histone) specificity, nuclear HATs can be grouped into four different families, Gcn5/PCAF (includes yeast Gcn5 and its human ortholog, PCAF), MYST (includes MOZ, Ybf2/Sas3, Sas2, and Tip60), p300/CBP (includes human paralogs p300 and CBP), and Rtt109 (named for regulator of Ty1 transposition gene product 109) [3, 34].
Corder, "Metformin suppresses hepatic gluconeogenesis through induction of SIRT1 and GCN5," Journal of Endocrinology, vol.
Besides the target of the ELONGATOR complex, SHY2/IAA3 gene is also the target of Arabidopsis GCN5 histone acetyltransferase and since its auxin-induced expression is not affected in elo mutants, it was suggested that there is a complex chromatin-related control and specificity in target gene selection.