Expression levels of Enpp1, Gck
, Pck1, Fas, Igfbp-1, and Apoe transcripts in the liver of rats in the cycle of fasting and refeeding.
The igfbp-1 and gck
gene expressions are regulated by nutritional status or the glucose levels.
For TPACK-G (See Table 2), two statistically significant differences identified were GK (F = 11.97, p < .001) and GCK
(F = 3.18, p < .05).
Together with Gck
, GLUT2 forms the glucose sensor that facilitates the entrance of glucose into the cell.
The individuals with autosomal dominant mutations in GCK
gene on chromosome 7p originally displayed an abnormal glucose sensing with stable mild hyperglycemia in maturity onset diabetes of the young T2DM (MODY) [75,76], which occurs at an age onset of 25 years or younger [77,78].
We also consistently observed markedly decreased expression and activity of Pepck, Gck
, G6pase, and Glut2, all enzymes that control gluconeogenic flux in the liver of TCDF-treated mice.
Despite a median 48.6 years of follow-up of 99 patients with GCK
MODY, also known as MODY 2, the prevalence and severity of retinopathy, nephropathy, peripheral neuropathy, cardiovascular disease, and peripheral vascular disease weren't significantly different from those of controls (JAMA 2014;311:279-86).
And we think that if they do, it might be because they later go on to develop type 2 diabetes; for instance, if they become obese and have a genetic predisposition in addition to having their GCK
[9.] YC Chan, HT Fung, CK Lee, SH Tsui, HK Ngan, MY Sy ML Tse, CW Kam, GCK
Wong, HK Tong, ACH Lit, TW Wong, FL Lau.
Berberine regulated Gck
, G6pc, Pck1 and Srebp1c expression and activated AMP-activated protein kinase in primary rat hepatCytes.
Glycogen use and release are dependent on 6-phosphoric acid enzymatic synthesis and hydrolysis, and these reactions are catalysed by glucokinase (GCK
) andglucose-6-phosphatase (G6Pase).
The eGFRs by GCK
and GCKR genotypes were substantially in the same trend to this analysis, with the marginally significant decreasing effect of PPARD T-842CT/C + C/C on eGFR, suggesting the influence of GCK
and GCKR polymorphisms on human renal functions (Table 3).