adiponectin

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ad·i·po·nec·tin

(ad'i-pō-nek'tin),
Protein hormone produced and secreted by adipocytes into the systemic blood circulation; causes sensitivity of peripheral tissues to insulin.
[adipo- + L. necto, to fasten, + -in]

adiponectin

(ăd′ə-pə-nĕk′tĭn)
n.
A polypeptide hormone that is secreted by fat cells and regulates glucose and lipid metabolism, especially by increasing insulin sensitivity and muscle uptake of glucose and by decreasing glucose production in the liver.

Adiponectin

A circulating protein encoded by ADIPOQ on chromosome 3q27, which is secreted exclusively by mature adipocytes. It is a key adipokine in the control of fat metabolism and insulin sensitivity, and has direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. It stimulates AMPK phosphorylation and activation in the liver and skeletal muscle, enhancing glucose utilisation and fatty acid hydrolysis. It antagonises TNF-alpha by down-regulating its expression in the liver, macrophages and elsewhere, and by counteracting its direct effects. It inhibits endothelial NF-kappa-B signalling by a cAMP-dependent pathway. It may play a role in cell growth, angiogenesis and tissue remodelling by binding and sequestering various growth factors with distinct binding affinities, depending on complex size—low, medium, or high molecular weight.

ad·i·po·nec·tin

(ad'i-pō-nek'tin)
Protective adipokine that reduces lipid accumulation and endothelial adhesion resulting from vascular injury; increases skeletal muscle oxidation of free fatty acids; reduces hepatic glucose output; increases peripheral insulin sensitivity.
[adipo- + L. necto, to fasten, + -in]

adiponectin

A cytokine derived from adipose tissue that has antidiabetic and antiatherosclerotic properties.
References in periodicals archive ?
The real estate investment trust has exchanged contracts on a further GBP28.0 million of disposals, including three retail parks and 10 pubs, at a blended net initial yield of 4.5% and 3.6% ahead of book value.
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The company has has also won a GBP28 million contract for the signalling component of the next phase of Reading station's GBP400 million remodelling programme in teh UK.
The GBP53.8m deal is a cash and debt transfer arrangement through which Infinis will pay SSE GBP28.1m and take on GBP25.7m of project debt.
ewido anti-spyware 4.0 is available as a download, with one year licence, for GBP19 +VAT for a single copy of ewido 4.0, or GBP28 +VAT for an ewido plus AVG bundle.
Adiponectin (Arcp30, AdipoQ, apM1, or GBP28), a novel 247-amino acid peptide, is secreted predominantly by adipocytes and accounts for ~0.05% of total serum proteins (1-4).
Title: Kosmos Author: Adam Bartos Published by: Princeton Architectural Press ISBN: 1-56898-308-5 Price: GBP28 Reviewer: Darren Ingram
NEA No: 03628, ISBN: 92-64-09782-1, OECD Ordering reference number: 662002093P1Price: USUSD 40, GBP28, 5150.
Over the half year to the end of September, PSINet Japan recorded turnover of GBP28 million (Euro 45 million).
(Alliance News) - Bank of Georgia Group PLC said Thursday unit JSC Bank of Georgia and International Finance Corp have signed a GEL100 million, about GBP28 million, loan agreement to support the local currency needs of Georgian micro, small and medium sized enterprises.
Merian Global Investors has a total of GBP28.9bn under management as of December 31, 2018.
Satisfactory Liquidity: Fitch views Voyage's liquidity as satisfactory with cash-on-balance sheet of GBP16.4 million at end-September 2017, and an undrawn revolving credit facility of GBP28 million, in the absence of short-term financial liability.