GATA5

GATA5

A gene on chromosome 20q13.33 that encodes a member of the GATA family of zinc finger transcription factors, which binds to hepatocyte nuclear factor-1alpha (HNF-1alpha), an interaction required to activate the intestinal lactase-phlorizin hydrolase promoter. GATA5 also binds to the CEF-1 nuclear protein-binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer, and may be involved in pathways that result in smooth muscle diversification.
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In addition, certain gene mutations (GATA5, NOTCH1, ACTA2) are associated with BAV defect, leaflet calcification and aortic dilation.
used sputum and serum to identify methylation targets for NSCLC and found thatp16, DAPK, PAX5b, and GATA5 were potential biomarkers for NSCLC [71].
Elliott et al., "Cardiac Tbox factor Tbx20 directly interacts with Nkx2-5, GATA4, and GATA5 in regulation of gene expression in the developing heart," Developmental Biology, vol.
Although this is not necessarily true, there exist at least three important maternal transcription factors and cofactors that play critical roles in fate determination: [beta]-catenin, (28,29) Gata.a (30,31) (a possible ortholog of vertebrate GATA4, GATA5, and GATA6; the original name was Gata-a), and the Zic-like protein Macho-1/Zic-r.a (Macho-1 is the original name and Zic-r.a is the new name).
Three GATA family members, GATA4, GATA5, and GATA6, have been detected in presumptive heart cells and have been shown to activate numerous myocardial genes.
The aberrant DNA methylation of certain promoter regions is linked to tumor formation, owing to the silencing of the transcription of well-established tumor suppressor genes, such as CDKN2A [4] [cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)], GATA5 (GATA binding protein 5), and DAPK1 (death-associated protein kinase 1) (9-11).
We designed 3 assays to detect hypermethylation in the promoters of 3 genes recognized to be involved in lung carcinogenesis (DAPK1, GATA5, and CDKN2A).
We used 1 or 2 [micro]L (approximately 25-50 ng) of DNA as the target for investigating the hypermethylation status of the CDKN2A, DAPK1, and GATA5 promoters.
Washington, Jan 13 (ANI): In a genetic study, researchers have found that a particular gene, called Gata5, acts in concert with a related gene to regulate early heart development in animals.
"We uncovered a role for the Gata5 gene, a role that has been unappreciated in vertebrate cardiac development.
We first validated this new assay on DNA with known methylation status and then demonstrated the detection of methylation for 3 tumor suppressor genes that are often found to be methylated in lung adenocarcinoma: CDKN2A, RASSF1, and GATA5 (GATA binding protein 5).
We performed MS-FLAG assays on 1 [micro]L bisulfite-treated DNA (corresponding to approximately 5 ng starting material) to investigate hypermethylation of promoter regions of RASSF1, p16, and GATA5. We also examined the methylation status of clinical samples via bisulfite sequencing.