GATA3


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GATA3

A gene on chromosome 10p15 that encodes a zinc finger protein belonging to the GATA family of transcription factors, which is a key regulator of T-cell development and plays an important role in endothelial cell biology.

Molecular pathology
GATA3 mutations cause hypoparathyroidism with sensorineural deafness and renal dysplasia.
References in periodicals archive ?
All the three hearing-impaired family members were identified to carry out the same GATA3 mutation.
The TH1, TH2, and TH17 markers Tbx21, Gata3, and Rorc, respectively, were not regulated on the transcriptional level (Figure 2(d)).
They were immunoreactive for OSCAR pankeratin and GATA3 and, thus, were considered consistent with the previously diagnosed PUC (Figure 4).
Therefore, we examined the expression of transcriptional factors for Th1 (T-bet, STAT1) and Th2 (GATA3) cells in the spleen using qPCR.
The tumour cells were negative for ER, PR, GATA3, GCDFP-15, CD56, synaptophysin and chromogranin.
In the lab and using genetically engineered mice, the Tscove team zeroed in on GATA3 and determined that interfering with its function causes stem cells to increase their self-renewal rate and thereby results in increased numbers of stem cells.
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).
"When GATA3 is present, it turns off many genes that are active in metastasis.
Nishimori, "Lgr4-deficient mice showed premature differentiation of ureteric bud with reduced expression of Wnt effector Lef1 and Gata3," Developmental Dynamics, vol.
To exclude other potential primary tumors, it is sometimes necessary for the pathologist to employ additional immunohistochemical markers, such as GATA3 and uroplakin II for urothelial carcinoma and SALL4 and SOX2 for germ cell tumors.
Caption: Figure 4: Immunohistochemical (IHC) stain 20x shows tumor cells to be negative for GATA3 (note: positive in breast primary).
(2) Jun kinase (JNK) and (3) extracellular signal-regulated kinase (ERK)1/ 2 following receptor ligation promote an activation of IRF1 that inhibits Foxp3 and GATA3 expressions [1].