GATA3

(redirected from GATA-binding protein 3)

GATA3

A gene on chromosome 10p15 that encodes a zinc finger protein belonging to the GATA family of transcription factors, which is a key regulator of T-cell development and plays an important role in endothelial cell biology.

Molecular pathology
GATA3 mutations cause hypoparathyroidism with sensorineural deafness and renal dysplasia.
References in periodicals archive ?
Abbreviations DNBS: 2,4-Dinitrobenzene sulfonic acid GATA-3: GATA-binding protein 3 LPL: Lamina propria T lymphocytes LSA: L4 somatic antigen STAT: Signal transducer and activator of transcription ROR[gamma]-T: RAR-related orphan receptor gamma T-bet: T-box expressed in T cells UC: Ulcerative colitis.
The second article focuses on papillary and nonpapillary breast lesions and their differential diagnosis; the diagnostic and prognostic IHC markers for triple-negative breast cancers, such as proline glutamic acid and leucine-rich protein (PELP1), GATA-binding protein 3 (GATA3), and androgen receptor (AR); and an example with aberrant expression of breast markers in lung adenocarcinoma.
The mRNA expression of signal transducer and activator of transcription-3, T-box transcription factor TBX21, interferon-y, forkhead box P3, GATA-binding protein 3, interleukin-10, and interleukin-5 also were analyzed using real-time polymerase chain reaction.
List of Abbreviations BCL-6: B-cell lymphoma-6 CK: Casein kinase GATA-3: GATA-binding protein 3 GSK-3: Glycogen synthase kinase-3 IFN: Interferon IL: Interleukin ITK: IL-2-inducible T cell kinase NFAT: Nuclear factor of activated T cells NF-[kappa]B: Nuclear factor kappa B ROR[gamma]t: Retinoic acid-related orphan receptor gamma t RUNX: Runt-related transcription factor STAT: Signal transducer and activator of transcription T-bet: T-Box protein expressed in T cells Th: T helper Treg: Regulatory T [T.sub.FH]: Follicular T helper Ub: Ubiquitin.