GATA5

(redirected from GATA binding protein 5)

GATA5

A gene on chromosome 20q13.33 that encodes a member of the GATA family of zinc finger transcription factors, which binds to hepatocyte nuclear factor-1alpha (HNF-1alpha), an interaction required to activate the intestinal lactase-phlorizin hydrolase promoter. GATA5 also binds to the CEF-1 nuclear protein-binding site in the cardiac-specific slow/cardiac troponin C transcriptional enhancer, and may be involved in pathways that result in smooth muscle diversification.
References in periodicals archive ?
We first validated this new assay on DNA with known methylation status and then demonstrated the detection of methylation for 3 tumor suppressor genes that are often found to be methylated in lung adenocarcinoma: CDKN2A, RASSF1, and GATA5 (GATA binding protein 5).
[4] Human genes: CDKN2A, cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); RASSFI, Ras association (Ra1GDS/AF-6) domain family 1; GATA5, GATA binding protein 5; DAPK, death-associated protein kinase; MGMT, O-6-methylguanine-DNA methyl-transferase.