increases myelination by oligoden drocytes and its deficiency delays recovery following cuprizone induced demyelination," PLoS ONE, vol.
Next, we determined the expression of TAM receptors and their ligands GAS6
and PROS1 as well as genes involved in EMT on these samples.
mediates adhesion of cells expressing the receptor tyrosine kinase AXL.
The research showed that when two Gas6
proteins linked with two Axls, the signals that were generated enabled cancer cells to leave the original tumour site, migrate to other parts of the body and form new cancer nodules, Science Daily reported.
A role of Gas6
in hemostasis has been shown by the study of mouse models, in which mice with Gas6
deficiency were protected against thrombosis (4).
However, in the present study, we find that Gas6
increases the suppressive effect of [CD4.sup.+][CD25.sup.+]Tregs on effector [CD4.sup.+]T cells.
Cohen, "TAM receptor ligands in lupus: protein S but not Gas6
levels reflect disease activity in systemic lupus erythematosus," Arthritis Research and Therapy, vol.
Preheat the oven to 200C/400F/ Gas6
. Grease a medium sized ovenproof gratin dish.
As previously announced, the trial met the safety and tolerability endpoints for the trial and demonstrated clinical proof-of-mechanism for AVB-S6-500 in neutralizing GAS6
, a key molecule in the AXL cancer survival pathway.
AVB-S6-500 is a novel high-affinity, soluble Fc-fusion protein designed to block the activation of the GAS6-AXL signaling pathway by intercepting the binding of GAS6
to its receptor AXL.
Among tumor infiltrating leukocytes TAMs produced the mitogen Gas6
accelerating primary tumor growth and metastasis .
(growth arrest-specific gene 6) is the last addition to the family of plasma vitamin K-dependent proteins.