is low-expressed in lung cancer tissues and regulates cell proliferation and apoptosis by activating p53 and E2F1 signaling pathways (10).
carried out lncRNA profiling from 213 GBMs using data from The Cancer Genome Atlas (TCGA) database and identified six lncRNAs including KIAA0495, MIAT, GAS5
, PARTI, PAR5, and MGC21881, whose weighted expressions are closely associated with the overall survival of GBM patients.
In addition, both Plexin C1 and its positive regulator GAS5
, a long non-coding RNA, were downregulated in glioma tissues and cell lines .
 identified six LncRNAs MALAT1, HOTAIR, lincRNA-p21, GAS5
, TUG1, and CCND1-ncRNA in HeLa and MCF-7 cells and their secreted exosomes.
Xia et al., "Decreased expression of long noncoding RNA GAS5
indicates a poor prognosis and promotes cell proliferation in gastric cancer," BMC Cancer, vol.
Chen et al., "Long non-coding RNA GAS5
suppresses pancreatic cancer metastasis through modulating miR-32-5p/PTEN axis," Cell & Bioscience, vol.
Leng et al., "Identification of long noncoding RNAs GAS5
, linc0597 and lnc-DC in plasma as novel biomarkers for systemic lupus erythematosus," Oncotarget, vol.
first demonstrated the role of growth arrest-specific 5 (GAS5
), a lncRNA upregulated in OA cartilage, in apoptosis and autophagy by sequestering miR-21.
Of eight possible lncRNA candidates (UCA1, TUG1, CCAT1, MEG3, Linc00152, HULC, MALAT1, and GAS5
), circulating HULC and Linc00152 were significantly upregulated in plasma samples from HCC patients during training and validation sets using qRT-PCR, with areas under the ROC curves of 0.78 and 0.85, respectively.
Other lncRNAs, such as GAS5
, act as decoy precluding the access of regulatory proteins to DNA .
Growth arrest-specific transcript 5 (GAS5
) encodes a single strand noncoding RNA (ncRNA) and, as its name suggests, can accumulate in growth-arrested cells .
To cook the rhubarb, heat the oven to Gas5