GADD45A

GADD45A

A gene on chromosome 1p31.2 that is upregulated in response to stressful growth-arrest conditions and exposure to DNA-damaging agents. The encoded protein activates the p38/JNK pathway via MTK1/MEKK4 kinase.
References in periodicals archive ?
Singh et al .[22] demonstrated that NCL acts as a key component of the complex involved in maintaining CD154 mRNA stability and regulating mRNA turnover in activated T-cells.[21] In addition, Zhang et al .[23] reported that the mRNA stability of growth arrest and DNA-damage-inducible alpha (GADD45a) was also regulated by NCL through binding to the GADD45a mRNA-coding region.
Kremer et al., "Combined GADD45A and thymidinephosphorylase expression levels predict response and survival of neoadjuvant-treated gastric cancer patients," Clinical Cancer Research, vol.
Deficiency of Per2 causes deregulation of Myc, cyclin A, cyclin D1, Mdm-2, and Gadd45a, while its dysfunctionality impairs apoptosis mediated by p53 by activating c-Myc signaling pathway.
Tang, "GADD45a regulates Olaquindox-induced DNA damage and S-phase arrest in human hepatoma G2 cells via JNK/p38 pathways," Molecules, vol.
Interestingly, CB-MSCs cultured in HFS, CS, and FBS alike demonstrated an increased response in growth arrest and DNA damage-inducible protein upregulation (GADD45A, growth arrest, and DNA damage-inducible 45 alpha) 4 hours after AcS.
It unexpectedly found bioeffects similar to Xray exposure, i.e., the gene Gadd45a was several hundred times differentially expressed.
Our data showed that several cell cycle related genes, such as DDIT3, PPP1R15A, and GADD45A, were upregulated in the propofol-treated group, while other genes that are involved in cell cycle progression, including CCNA2, CDKN3, CDC2, and CDC25B, were downregulated.
Furthermore, there is considerable overlap in the genes regulated by both FOXO3A and MYC, both in those related to growth promotion such as CCND2, CDK4, and CCNE2 and in those related to growth inhibition such as BBC3, CDKN1B, and GADD45A [35, 36], suggesting that the expression of such genes is regulated by both FOXO3A and MYC in an antagonistic manner.
Lindroth et al., "Long noncoding RNA TARID directs demethylation and activation of the tumor suppressor TCF21 via GADD45A," Molecular Cell, vol.
The expressions of 5-FU-related genes including thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD), and thymidine phosphorylase (TP) and cisplatin-related genes including excision repair cross complementing 1 (ERCC1), ERCC4, KU80 (an enzyme involved in nonhomologous end joining repair) and growth arrest and DNA-damage-inducible protein 45 alpha (GADD45A) were analyzed using quantitative real-time PCR.
Furthermore, the results of qRT-PCR showed that lupeol pre-treatment significantly (p < 0.05) decreased mancozeb-induced expression of DNA damage (p53, MDM2, COX-2, GADD45a and p21) and increased expression of DNA repair responsive genes (hOGGl and XRCC1) in CHLs.