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For the sake of clarity and result reproducibility, we will outline an explicit calculation as follows: For instance, the gene GABPB2 has 232 regulators (in-degree, inDeg) but 2829 targets (out-degree, outDeg) in the database.
In this network, genes with the highest out-degree are SP1, MAZ, ELF4, ELF1, ELF2, SPI1, ELK1, ELK4, GABPA, and GABPB2. The subnetwork containing only the targets of those genes has 140,318 interactions with 7913 out of the total of genes.
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