GABPA

GABPA

A gene on chromosome 21q21.3 that encodes the alpha subunit of the GA-binding protein, which forms a tetrameric complex with two beta subunits and stimulates transcription of target genes. The encoded protein may downregulate cytochrome oxidase expression and may play a role in nuclear control of mitochondrial function.
References in periodicals archive ?
Genes like NRF1, SPIB, GABPA, or TFAP2A present a high RI since they do not have regulators within the database.
Another one, GABPA, whose binding sites are overrepresented in methylated regions of primary mouse hematopoietic stem cells [32], shows evidence of GABPA binding being methylation-sensitive as demonstrated by Lucas et al.
Triptolide decreased ERK and AKT phosphorylation, and GABPa expression in colon cancer cells.