Several classes of antibiotics have been evaluated in clinical studies of the treatment of GABHS
pharyngotonsillitis, including the penicillins, cephalosporins, macrolides, ketolides, and clindamycin.
Patients in the penicillin group had a significantly lower total number of AHS than those in the cefdinir group and also a significantly lower number of those AHS that possess the capability of interfering against GABHS
Ebel recommended that clinicians employ a tool developed by McIssac and colleagues (2000) to support clinical decision-making regarding the likelihood of GABHS
pharyngitis based on presenting signs and symptoms.
In the US, GABHS
is the cause of acute pharyngitis in 5% to 10% of adults and 15% to 30% of children.
All available medical records of those patients identified as having suffered a complication of GABHS
were then reviewed in an effort to assess both coding accuracy and whether a false laboratory test (culture or antigen test) might have preceded the complication.
Study design and validity The researchers established baseline values for the prevalence of GABHS
infection and sensitivity and specificity of enzyme-linked immunoassay (EIA) and OIA rapid tests, using data from their local hospital laboratory.
9) with suspected GABHS
pharyngitis in a private pediatric practice.
Penicillin, introduced in the 1940s, has been the standard treatment for patients with GABHS
pharyngitis and other streptococcal illness.
7] We attributed this patient's nephritis to GABHS
infection because she had a documented positive throat culture (as did her son) that became negative after treatment with penicillin.
4] Despite the consistent susceptibility of the GABHS
organism to penicillin, treatment of this infection is only 75% to 94% successful in eradicating the organism.
In one report, 20 patients from the Rocky Mountain region became ill (1986 to 1988) with a GABHS
toxic shock syndrome.
It is an abnormal autoimmune response due to molecular mimicry between the M Protein on GABHS
cell wall and cardiac myosin.