PIGU

(redirected from GAB1)

PIGU

A gene on chromosome 20q11.22 that encodes a component of the glycosylphosphatidylinositol (GPI) transamidase complex possibly involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.
References in periodicals archive ?
miR-150 influences B-cell receptor signaling in chronic lymphocytic leukemia by regulating expression of GAB1 and FOXP1.
Chmielowiec et al., "Gab1 and Mapk signaling are essential in the hair cycle and hair follicle stem cell quiescence," Cell Reports, vol.
Tumor cells showed nuclear YAP1 and cytoplasmic GAB1 staining, while nuclear staining for fi-catenin and staining for p53 was negative.
Immunohistochemical surrogate markers such as GAB1, YAP1, [beta]-catenin, and Filamin A are reliable tools in subclassifying Medulloblastoma.
(71-73) Cytogenomic data from the MIP array are also used along with immunostains for b-catenin, GAB1, and YAP1 in order to gain additional subclassification data.
HS: heparan sulfate; PIP2: phosphatidylinositol 4,5-bisphosphate; IP3 inositoltriphosphate; PLC[gamma]: phospholipase C; DAG: diacylglycerol; GRB2: growth factor receptor- bound protein 2; GAB1: GRB2 associated binding protein 1; Sos: son of sevenless; MEK: MAPK/ERK kinase; MAPK: mitogen activated protein kinase; STAT: signal transducer and activator of transcription; TFs: transcription factors.
The Ras-MAPK pathway is activated by insulin after the binding of Grb2 to phosphorylated IRSs or SH2 domain proteins (Shc and GAB1).
When protein EGF (Egf) is bound to its receptor EGFR phosphorylated on tyrosine ([EgfR - Yphos]), the GRB2-associated-binding protein Gab1 or Gab2 phosphorylated on tyrosine is present ([gab:GabS - Yphos]), the Ras guanyl-releasing protein 3 RasGrp3 or protein Sos1 phosphorylated on tyrosine is present, Pi3k is present, the protein Shp2 phosphorylated on tyrosine is present, and the inside of the membrane (Cli) contains Hras loaded with guanosine diphosphate GDP, then Hras switches its load to guanosine 5'-triphosphate GTP [51].
Huang et al., "Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-[alpha]-induced c-Jun and NF-[kappa]B activation and adhesion molecule expression," Circulation Research, vol.
Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-a'-induced c-Jun and NF-B activation and adhesion molecule expression.
Huang et al., "Insulin-like growth factor-1 enhances inflammatory responses in endothelial cells: role of Gab1 and MEKK3 in TNF-a-induced c-Jun and NF-[kappa]B activation and adhesion molecule expression," Circulation Research, vol.
In the case of ERK, the activation through these receptors leads to the recruitment of downstream effectors including growth factor receptor-bound protein 2 (Grb2) and protein tyrosine phosphatase non-receptor type 11 (PTPN11/Shp2), leading to the recruitment of Gab1 (GRB2-associated binding protein 1) and SOS (Son of Sevenless).