EPCAM

(redirected from GA733-2)

EPCAM

A gene on chromosome 2p21 that encodes a carcinoma-associated antigen expressed on most normal epithelial cells and gastrointestinal carcinomas, which functions as a homotypic calcium-independent cell adhesion molecule. EPCAM is thought to function as a relay molecule between intestinal epithelial cells and intraepithelial lymphocytes at the mucosa, providing an immune barrier to infection. It is of interest in oncology as a target for cancer immunotherapy. It upregulates expression of FABP5, MYC and cyclins A and E.

Molecular pathology
Defects in EPCAM cause congenital tufting enteropathy (diarrhoea type 5).
References in periodicals archive ?
Briefly, epithelial cell adhesion molecule (EPCAM; also known as GA733-2)-positive and mucin 1, cell surface associated (MUC1)-positive cells were targeted, followed by RNA isolation and subsequent gene expression analysis by reversetranscription (RT) and multiplex PCR, detecting the tumor-associated transcripts EPCAM, MUC1, and mucin 16, cell surface associated (MUC16; also known as CA125) (AdnaTest OvarianCancerDetect; AdnaGen AG).
[8] Human genes: ERCC1, excision repair cross-complementation group 1; EPCAM, epithelial cell adhesion molecule (also known as GA733-2); MUC1, mucin 1, cell surface associated; MUC16, mucin 16, cell surface associated (also known as CA125); ACTB, actin, beta; PPIC, peptidylprolyl isomerase C (cyclophilin C).
Ye and Shi (75) found changes in genes involved in carcinogenesis such as Src, MAPK and its related proteins, cell cycle regulation, checkpoint suppressor 1, wnt-13 and carcinoma-associated antigen GA733-2 after a 2 h exposure to 300 [micro]M soluble chromate in human lung tumour cells.