G6PD deficiency

G6PD deficiency

 Glucose-6-phosphate dehydrogenase deficiency, see there.

Glucose-6-phosphate dehydrogenase (G6PD) deficiency

An inherited disorder in which the body lacks an enzyme that normally protects red blood cells from toxic chemicals. When people with this condition take certain drugs, their red blood cells break down, causing anemia. This may also happen when they have a fever or an infection. The condition usually occurs in males. About 10% of black males have it, as do a small percentage of people from the Mediterranean region.
References in periodicals archive ?
Comment: There have been two previous case reports of acute hemolysis induced by high-dose intravenous vitamin C in patients with G6PD deficiency. In both of these previous reports, the hemolysis-inducing dose was 80 g.
A study done on 98,256 newborn showed the prevalence of homocysteinemia, hyperglycemia, MSUD, phenylketonuria, hypothyroidism, and G6PD deficiency. Another expanded study started in 2000 in Hyderabad for amino acid disorders, CH, congenital adrenal hyperplasia (CAH), G6PD deficiency, biotinidase deficiency, galactosemia, and cystic fibrosis, revealed high prevalence of CH followed by CAH and G6PD deficiency.
G6PD deficiency is an X-linked disorder that renders erythrocytes vulnerable to oxidative stress and haemolysis.
Patient was diagnosed to have methemoglobinemia patient was planned for methylene blue therapy, for which G6PD deficiency was ruled out.
We affirmed the diagnosis of acute viral hepatitis E with G6PD deficiency. This case had a different prospect of HEV infection and its coexistence with G6PD deficiency, which lead to investigations, management and avoidance of complications of the disease.
--Most common genetic disorders are thalassaemia, sickle cell, anaemia, haemophilia and G6PD deficiency
The most common are blood disorders such as thalassaemia, sickle cell, anaemia, haemophilia and G6PD deficiency.
It is important to consider the possibility of G6PD deficiency in a patient prior to administration of rasburicase, as it can lead to hemolysis in these patients [17].
Drugs avoided in G6PD deficiency should also be restricted in GSSD.
However, breastfeeding an infant with G6PD deficiency could lead to hemolytic anemia.
Several maternal and neonatal risk factors such as preeclampsia, G6PD deficiency, ABO incompatibility, prematurity, birth weight, intrauterine growth retardation, metabolic abnormalities, neonate's gender, birth weight, and nutrition have been identified as risk factors for neonatal jaundice [8, 9].
Here we report on the case of a patient in whom the first manifestations of G6PD deficiency occurred at age 86.