GAPDH

(redirected from G3PD)
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GAPDH

A gene on chromosome 12p13 that encodes glyceraldehyde-3-phosphate dehydrogenase, which has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities. It catalyses the reversible
oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide, an important energy-yielding step in carbohydrate metabolism. GADPH participates in nuclear events, including transcription, RNA transport, DNA replication and apoptosis.
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The genetic interpretation of the remaining enzymes (Acp, G3pd, Idh, and Pgm) were based on the generally conserved enzyme substructure, subcellular location, and isozyme number in higher plants (Weeden and Wendel 1989; Kephart 1990).
The loci Got-3, Mdh-1, Mr, and Pgm were variable in all populations while Gdh, G3pd, Got-1, Got-2, Mdh-2, Pgi-2, Pk-1, and Tpi-1 were only variable in a subset of the populations and typically consisted of a predominant allele and one or more alleles at very low frequency.
Locus f [Theta] F G3pd -0.007 0.006 -0.001 Gdh 0.286 -0.007 0.281 Got-1 -0.011 0.007 -0.004 Got-2 -0.038 0.018 -0.019 Got-3 0.222 0.008 0.228 Mdh-1 0.111 0.038 0.145 Mdh-2 0.378 0.104 0.443 Mr 0.522 0.033 0.538 Pgi-2 0.133 0.025 0.154 Pgm 0.078 0.020 0.096 Pk-2 -0.006 0.043 0.037 Tpi-2 0.215 0.175 0.352 Mean 0.275 0.034 0.300 SD 0.136 0.008 0.131 Local Spatial Structure