G-CSF


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G-CSF

Abbreviation for granulocyte colony-stimulating factor.

G-CSF

A biological response modifier encoded by CSF3 on chromosome 17q11.2-q12, which is produced by endothelial cells, fibroblasts, and macrophages. It stimulates granulocyte production in bone marrow (BM), acting synergistically with IL-3 to stimulate proliferation of other marrow cells. The recombinant DNA form is filgrastim (Neupogen).
 
Activity
G-CSF stimulates granulocyte production in BM suppressed by chemotherapy and radiotherapy, and reduces infections in cancer patients. It can induce terminal maturation of myeloid leukaemia cells, resulting in complete haematologic and cytologic remission, and can suppress self-renewal. It is useful in patients with AIDS or leukaemic relapse after allogeneic BM transplantation.
 
Adverse effects
Nausea, bone pain, rash.

G-CSF

Granulocyte colony-stimulating factor Molecular therapeutics A biological response modifier, the recombinant DNA form of which is filgrastim–Neupogen® Activity G-CSF stimulates granulocyte production in BM suppressed by chemotherapy, RT, serving to ↓ infections in Pts with malignancy; G-CSF can induce terminal maturation of myeloid leukemia cell lines and suppress self-renewal, and is thus useful in Pts with AIDS or leukemic relapse after allogeneic BMT Adverse effects Nausea, bone pain, rash. See Biological response modifiers, Colony-stimulating factors. Cf GM-CSF.

G-CSF

Abbreviation for granulocyte colony-stimulating factor.
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References in periodicals archive ?
(7) and preferred giving G-CSF to the doe (mother) instead of performing chronic fetal arterial catheterization, a technically demanding intervention.
Inflammation-mediated fetal injury by maternal granulocyte-colony stimulating factor and high-dose intra-amniotic endotoxin in the caprine model/Maternal granulosit koloni stimulan faktor ve yuksek doz intra-amniyotik endotoksin ile enflamasyon aracili fetal beyin hasari keci modeli
The mean number of the primordial follicles was 24[+ or -]4 in the control group, 33[+ or -]6 in the BMSC group, 31[+ or -]6 in the G-CSF group, and 42[+ or -]4 in the coadministration group.
Bone Marrow Stromal Cells with the Granulocyte Colony-Stimulating Factor in the Management of Chemotherapy-Induced Ovarian Failure in a Rat Model
In this study, it was found that BMSCs + JSSQ group had the best effect in reducing ALT and increasing ALB after intervention therapy, which was significantly better than the BMSCs + G-CSF group, indicating that BMSCs + JSSQ group was effective in cirrhotic rats.
Observation of the effect of bone marrow mesenchymal stem cell transplantation by different interventions on cirrhotic rats
Our septic population presented higher plasma concentration of IL-6, IL-8, G-CSF, IL-10 on ICU admission (D0) than healthy volunteers.
T helper type cytokines in sepsis: time-shared variance and correlation with organ dysfunction and hospital mortality
Table: Subgroup analysis of mean rise in ANC with G-CSF treatment.
Granulocyte-colony stimulating factor in neonatal sepsis with leukopenia: A prospective cohort study
However, the results of studies are not consistent and a study in mice by Kong et al22 did not reveal any positive effect of G-CSF or GM-CSF on atherosclerosis, instead it was shown by the study that G-CSF and GM-CSF induce atherosclerosis in mice.
EFFECTIVENESS OF GRANULOCYTE COLONY-STIMULATING FACTOR IN REDUCTION OF ATHEROSCLEROTIC LESIONS IN RABBIT
We observed that G-CSF administration increased SDF-1 (Figure 4(a)) and Ang-2 (Figure 4(b)), but not Ang-1 (Figure 4(c)) plasma levels in all analyzed individuals.
Very Small Embryonic-Like Stem Cells, Endothelial Progenitor Cells, and Different Monocyte Subsets Are Effectively Mobilized in Acute Lymphoblastic Leukemia Patients after G-CSF Treatment
Abbreviations G-CSF: Granulocyte colony-stimulating factor HAX1: HS1-associated protein X1 ELANE: ELA2 elastase, neutrophil expressed SCN: Severe congenital neutropenia.
Novel HAX1 Gene Mutation in a Vietnamese Boy with Severe Congenital Neutropenia
G-CSF Pretreatment Induced LPS Sensitization in LEW Rats but Not in BN Rats.
The LPS Responsiveness in BN and LEW Rats and Its Severity Are Modulated by the Liver
g/[m.sup.2]) with G-CSF, while the results of other studies have shown
AUTOLOGOUS STEM CELL TRANSPLANTATION FOR THE TREATMENT OF HEMATOLOGICAL MALIGNANCIES IN THE CLINICAL CENTER OF VOJVODINA/AUTOLOGNA TRANSPLANTACIJA MATICNIH CELIJA HEMATOPOEZE ULECENJU HEMATOLOSKIHMALIGNITETA U KLINICKOM CENTRU VOJVODINE
Intervention group subjects received 300 [micro]g of G-CSF (Filgrastim, Switzerland), transvaginally by using an insemination catheter (Prodimed, France).
Efficacy of Intrauterine Injection of Granulocyte Colony Stimulating Factor (G-CSF) on Treatment of Unexplained Recurrent Miscarriage: A Pilot RCT Study
Granulocyte colony-stimulating factor (G-CSF) exerts anti-inflammatory and antiapoptosis effects and stimulates the proliferation of neural stem and progenitor cells in the brain.
Effects of granulocyte colony-stimulating factor treatment in children and patients with cerebral palsy: a preliminary report

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