G-CSF


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G-CSF

G-CSF

granulocyte colony-stimulating factor.

G-CSF

G-CSF

A biological response modifier encoded by CSF3 on chromosome 17q11.2-q12, which is produced by endothelial cells, fibroblasts, and macrophages. It stimulates granulocyte production in bone marrow (BM), acting synergistically with IL-3 to stimulate proliferation of other marrow cells. The recombinant DNA form is filgrastim (Neupogen).
 
Activity
G-CSF stimulates granulocyte production in BM suppressed by chemotherapy and radiotherapy, and reduces infections in cancer patients. It can induce terminal maturation of myeloid leukaemia cells, resulting in complete haematologic and cytologic remission, and can suppress self-renewal. It is useful in patients with AIDS or leukaemic relapse after allogeneic BM transplantation.
 
Adverse effects
Nausea, bone pain, rash.

G-CSF

Granulocyte colony-stimulating factor Molecular therapeutics A biological response modifier, the recombinant DNA form of which is filgrastim–Neupogen® Activity G-CSF stimulates granulocyte production in BM suppressed by chemotherapy, RT, serving to ↓ infections in Pts with malignancy; G-CSF can induce terminal maturation of myeloid leukemia cell lines and suppress self-renewal, and is thus useful in Pts with AIDS or leukemic relapse after allogeneic BMT Adverse effects Nausea, bone pain, rash. See Biological response modifiers, Colony-stimulating factors. Cf GM-CSF.

G-CSF

Abbreviation for granulocyte colony-stimulating factor.

G-CSF

granulocyte-colony stimulating factor.
References in periodicals archive ?
G-CSF in a mouse spinal cord hemisection recruits microglia to the injury site in the first 72h after spinal cord injury [14].
Similarly, human MNCCD34+ mobilized by G-CSF led to stem cell population exclusively in injured myocardium two days after intravenous injection in rat, at 15 weeks new blood vessel formation in the infarct bed and proliferation of preexisting vasculature were observed (7).
Furthermore, both G-CSF and stem cells can induce the production of the earlier-mentioned factors.
Results of one year's worth of SPECT stress tests nailed how earlier start of G-CSF therapy in heart attack patients improves blood flow, access to essential energy and overall cardiac function.
G-CSF (5[micro]g/kg/day) was administered subcutaneously for 5 consecutive days during the first, second, third, sixth, and twelfth months.
M2 EQUITYBITES-17 August 2010-BAC and Octapharma announce collaboration expansion for G-CSF Custom Ligand(C)2010 M2 COMMUNICATIONS http://www.
The study compared hematopoietic stem cell yield from patients treated with Mozobil in combination with G-CSF to patients treated with G-CSF in combination with placebo.
for G-CSF (filgrastim), its first biosimilar product.
It is assumed that about 20% of cases are related to autoimmune disorders and about 40-50% of cases are unexplained RM G-CSF (Granulocyte Colony-stimulating Factor) is a glycoprotein that is secreted from endothelial cells, macrophages and some other immune system cells (6).
The company stated that the Phase 3 GENESIS trial is aimed at evaluating the safety, tolerability and efficacy of the combination treatment of BL-8040 and granulocyte colony-stimulating factor (G-CSF), as compared to the control arm of placebo and G-CSF.