G-CSF


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G-CSF

G-CSF

A biological response modifier encoded by CSF3 on chromosome 17q11.2-q12, which is produced by endothelial cells, fibroblasts, and macrophages. It stimulates granulocyte production in bone marrow (BM), acting synergistically with IL-3 to stimulate proliferation of other marrow cells. The recombinant DNA form is filgrastim (Neupogen).
 
Activity
G-CSF stimulates granulocyte production in BM suppressed by chemotherapy and radiotherapy, and reduces infections in cancer patients. It can induce terminal maturation of myeloid leukaemia cells, resulting in complete haematologic and cytologic remission, and can suppress self-renewal. It is useful in patients with AIDS or leukaemic relapse after allogeneic BM transplantation.
 
Adverse effects
Nausea, bone pain, rash.

G-CSF

Granulocyte colony-stimulating factor Molecular therapeutics A biological response modifier, the recombinant DNA form of which is filgrastim–Neupogen® Activity G-CSF stimulates granulocyte production in BM suppressed by chemotherapy, RT, serving to ↓ infections in Pts with malignancy; G-CSF can induce terminal maturation of myeloid leukemia cell lines and suppress self-renewal, and is thus useful in Pts with AIDS or leukemic relapse after allogeneic BMT Adverse effects Nausea, bone pain, rash. See Biological response modifiers, Colony-stimulating factors. Cf GM-CSF.

G-CSF

Abbreviation for granulocyte colony-stimulating factor.
References in periodicals archive ?
The mean number of the primordial follicles was 24[+ or -]4 in the control group, 33[+ or -]6 in the BMSC group, 31[+ or -]6 in the G-CSF group, and 42[+ or -]4 in the coadministration group.
In this study, it was found that BMSCs + JSSQ group had the best effect in reducing ALT and increasing ALB after intervention therapy, which was significantly better than the BMSCs + G-CSF group, indicating that BMSCs + JSSQ group was effective in cirrhotic rats.
Our septic population presented higher plasma concentration of IL-6, IL-8, G-CSF, IL-10 on ICU admission (D0) than healthy volunteers.
However, the results of studies are not consistent and a study in mice by Kong et al22 did not reveal any positive effect of G-CSF or GM-CSF on atherosclerosis, instead it was shown by the study that G-CSF and GM-CSF induce atherosclerosis in mice.
We observed that G-CSF administration increased SDF-1 (Figure 4(a)) and Ang-2 (Figure 4(b)), but not Ang-1 (Figure 4(c)) plasma levels in all analyzed individuals.
Abbreviations G-CSF: Granulocyte colony-stimulating factor HAX1: HS1-associated protein X1 ELANE: ELA2 elastase, neutrophil expressed SCN: Severe congenital neutropenia.
G-CSF Pretreatment Induced LPS Sensitization in LEW Rats but Not in BN Rats.
Intervention group subjects received 300 [micro]g of G-CSF (Filgrastim, Switzerland), transvaginally by using an insemination catheter (Prodimed, France).
Granulocyte colony-stimulating factor (G-CSF) exerts anti-inflammatory and antiapoptosis effects and stimulates the proliferation of neural stem and progenitor cells in the brain.