amphotericin B

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amphotericin B

 [am″fo-ter´ĭ-sin]
an antifungal agent and antibiotic used to treat deep-seated fungal infections, especially histoplasmosis, and also to treat cutaneous and mucocutaneous candidiasis. It may be applied topically or administered intravenously or by intracavitary instillation. Anorexia, chills, fever, and headache may occur as side effects. Renal damage with evidence of renal tubular acidosis occurs, but usually clears when the drug is discontinued.

am·pho·ter·i·cin

, amphotericin B (am'fō-tār'i-sin),
An amphoteric polyene antibiotic prepared from Streptomyces nodosus and available as the sodium deoxycholate complex; also a nephrotoxic antifungal agent used extensively in the treatment of systemic mycoses.

amphotericin B

(ăm′fə-tĕr′ĭ-sĭn)
n.
An antibiotic derived from strains of the actinomycete Streptomyces nodosus and used to treat systemic fungal infections.

amphotericin B

Infectious disease A heptaene macrolide antibiotic produced by the bacteria, Streptomyces nodosus, administered IV Effective against Blastomycosis dermatitidis, Candida, Coccidioides immitis, Cryptococcus neoformans, H capsulatum, Paracoccidioides braziliensis, Torulopsis glabrata Adverse effects Severe–fever, azotemia, nephrotoxicity, chills, headache, anorexia, N&V, diarrhea, kidney damage, BM suppression Lab Hypochromic normocytic anemia, neutropenia See Amphotec, Liposome.

Amphotericin B (Fengizone)

An antifungal medication, prescribed for topical or systemic use in treating fungal infections.

antifungal agent 

Any substance which destroys or prevents the growth of fungi. It is one of the antibiotic groups. There are several classes of antifungal drugs: Polyenes, which cause an increase in fungal cell wall permeability leading to its death. Examples: amphotericin B, natamycin, nystatin. Azoles, which act either by inhibiting the synthesis of ergosterol, a component of fungal cell wall or by causing direct wall damage. Examples: clotrimazole, econazole, fluconazole, itraconazole, ketoconazole, miconazole. Pyrimidines, which interfere with the normal function of fungal cells. Example: flucytosine. Syn antimycotic agent.

am·pho·ter·i·cin

, amphotericin B (amfō-teri-sin)
An amphoteric antibiotic and nephrotoxic antifungal agent used extensively to treat systemic mycoses.
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