fructose-bisphosphate aldolase


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fruc·tose-bis·phos·phate al·dol·ase

(fruk'tōs bis-fos'fāt al'dol-ās),
Fructose-1,6-bisphosphate triophosphate-lyase; an enzyme reversibly cleaving fructose 1,6-bisphosphate to dihydroxyacetone phosphate and glyceraldehyde 3-phosphate; also acts on certain ketose 1-phosphates; deficient in individuals with hereditary fructose intolerance (aldolase B isozyme); a deficiency of aldolase A leads to erythrocyte aldolase deficiency with nonspherocytic hemolytic anemia. Compare: hereditary fructose intolerance.
Synonym(s): 1, 6-diphosphofructose aldolase, 1-phosphofructaldolase, diphosphofructose aldolase, fructoaldolase, fructose 1, 6-bisphosphate triosephosphate-lyase, fructose 1, 6-diphosphate aldolase, fructose 1-monophosphate aldolase, fructose 1-phosphate aldolase, fructose-diphosphate aldolase, ketose-1-phosphate aldolase, phosphofructoaldolase, SMALDO, zymohexase
Farlex Partner Medical Dictionary © Farlex 2012
References in periodicals archive ?
10591 Hemoglobin subunit alpha 4 P68138 Bt.88733 Actin, alpha skeletal muscle 5 Q3T149 Bt.4415 Heat shock protein beta-1 6 A6QLL8 Bt.22533 Fructose-bisphosphate aldolase 7 Q9XSC6 Bt.3651 Creatine kinase M-type 8 Q5KR49 Bt.
The transcription of glyceraldehyde 3-phosphate dehydrogenase, enolase, succinyl-CoA synthase alpha subunit, isocitrate dehydrogenase, pyruvate kinase, and fructose-bisphosphate aldolase was significantly decreased in SAE, approximately 0.8-, 0.8-, 0.6-, 0.75-, 0.72-, and 0.7-fold lower than that in WT, respectively (Figure 3).
Nearly all of the proteins altered in significant amounts were identified as enzymes associated with important metabolic pathways, such as alcohol dehydrogenase, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), Xaa-His dipeptidase, ornithine carbamoyltransferase, putative O-acetylserine lyase, enolase (2-phosphoglycerate dehydratase), fructose-bisphosphate aldolase, and cysteine synthase.
Up-regulated proteins are de(ta(3,5)-de!ta(2,4)-dienoyl-CoA isomerase, mitochondrial, platelet-activating factor acetylhydrolase IB subunit beta, endoplasmic reticulum protein ERP29 (ERP29), protea-some subunit beta type-6, fructose-bisphosphate aldolase A, triosephosphate isomerase (TIM), and D-3-phosphoglycerate dehydrogenase (3-PGDH), while down-regulated proteins are TAR DNA-binding protein 43 (TDP-43), splicing factor, arginine/serinerich 1 (SF2/ASF), cDNA FLJ55253 highly similar to actin cytoplasmic 1, eukaryotic translation initiation factor 3 subunit I (eIF3i), and actin aortic smooth muscle.