DACT1

(redirected from Frodo)

DACT1

A gene on chromosome 14q23.1 that encodes a protein which upregulates DVL2-mediated signalling pathways during development. DACT1 binds to DVL2 and impedes CTNNB1/beta-catenin degradation, thereby enhancing transcriptional activation of target genes of the Wnt signalling pathway.
References in periodicals archive ?
Frodo, the story's central character, struggled with the call to leave his familiar home in the Shire and embark on a journey fraught with danger.
The many maimed characters in Tolkien's fiction are categorized and characterized in Irina Metzler's "Tolkien and disability." About Frodo, she writes, "One may note [...] the trinity of wounds [...] that draws association with the Christian trinity.
Mione said: "They are bravely taking over from Frodo Baggins, who was blind from birth but sadly died unexpectedly just over a month ago.
Children are responsible for exercising, feeding and cleaning Frodo and Bilbo Baggins the pygmy goats.
Frodo, named after the Lord of the Rings character, was rescued by the RSPCA.
"The others cast themselves down upon the fragrant grass, but Frodo stood awhile lost in wonder.
Flame-haired Ed reckons they'd look like an odd couple from The Hobbit - casting himself in the role of Frodo Baggins.
It is a fairytale nale to a story that started in October 2012 when Ayla and her mum Joanne A Forster, from Cote Hill Riding Centre, bought a newly backed, very green Connemara cross oroughbred pony called Frodo Baggins.
At a deeper level, these main characters, Aragorn, Gandalf, and Frodo, embody the qualities of the three persons of the Holy Trinity, Father, Son, and Holy Spirit.
Though clearly best known throughout the world for his indelible work as Frodo in "The Lord of the Rings" trilogy, Wood has spent a significant portion of his career over the past two decades toiling in edgy films that benefitted from his willingness to tackle tough characters in complex stories.
Individual topics include examinations of the unhealed wounds of Frodo Baggins, incorporeality and transformation, Frodo's body luminality, health and ecology in the context of war; orc bodies' relationship with perversion and redemption, female bodies and femininities, a body of myth representing Sauron, Tolkien and the female bodies, the gifting economy of Middle-earth; and physicality in The Hobbit.
Courageous canines Frodo Baggins, Sherlock and Flag have already completed the West Highland Way without leads.