Thus, the ability to perceive touch applied with von Frey hairs decreases with age as has been shown in several large studies with quantitative sensory testing [48, 49].
Abbreviations CIMT: Constraint-induced movement therapy D2: Index finger GOT: Grating orienting task [DELTA]GOT: Difference in grating orientating task (posttest value--pretest value) SSDT: Shape-sorter-drum task [DELTA]SSDT: Difference in shape-sorter-drum task (posttest value--pretest value) t1: Baseline evaluation t2: Treatment evaluation TFD: Temporary functional deafferentation VFHT: von Frey hair testing VFHT-D2: von Frey hair testing at the index finger [DELTA]VFHT-D2: Difference in von Frey hair testing at the index finger (posttest value--pretest value) VFHT-FA: von Frey hair testing at the forearm [DELTA]VFHT-FA: Difference in von Frey hair testing at forearm (posttest value--pretest value) n.s.: Not significant.
For mechanical allodynia, we measured the withdrawal threshold of the tail in response to a series of von Frey hairs (log units: 3.61, 3.84, 4.08, 4.31, 4.56, 4.74, 4.93, and 5.18; equivalent in bending force to 0.4, 0.6, 1.0, 2.0, 4.0, 6.0, 8.0, and 15.0 g; Stoelting, USA).
On day 0, a tail immersion test or von Frey hair test was performed and then oxaliplatin (6 mg/kg) or vehicle (5% glucose solution) was intraperitoneally injected, followed by an oral administration of GBT or saline.