storage lesion

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storage lesion

Transfusion medicine The constellation of changes occurring in a unit of packed red cells during storage. See Red cell preservatives.
Storage lesions
Ammonium to 470 µmol/L–US: 800 µg/dL
Free Hb in plasma from 82 to 6580 mg/L–US: 8.2 to 658 mg/dL
K+ from 4.2 to 78.5 mmol/L–US: 4.2 to 78.5 mEq/L
ATP from 100% to 45%
2,3 DPG to < 10% of original levels–replenished within 24 hours of transfusion
Labile proteins, eg complement, fibronectin and coagulation factors ↓ to negligible
Na+ from 169 to 111 mmol/L–US: 169 to 111 mEq/L
pH from 7.6 to 6.7
Adverse physiologic effects of stored blood is negligible in the absence of a previous compromise of the Pt's–recipient's status

storage lesion

In blood banking and transfusion therapy, the biochemical and structural degradation of blood cells that occurs over time.
See also: lesion
References in periodicals archive ?
After transfusing of stored RBC, the accumulating of free Hb further scavenge NO and result in a decrease of NO bioavailability.
When the scavenging capacity of Hp is exceeded, the free Hb scavenges endothelial-derived NO to form met-Hb and nitrite.
Free Hb breaks down into dimer and monomer which freely diffuse into the renal tubules and the sub-endothelium leading to renal toxicity.
Currently the anti-Xa assay used in our hospital is claimed to be insensitive to free Hb (up to 200 mg/dL) and bilirubin (up to 6.
Alter 35 d of storage both UCB-PRC and ADB-PRC samples exhibited significant differences from the initial free Hb, intracellular ATP, and pH values.
Hemoglobin (Hb) is the major erythrocyte protein, and measurement of free Hb in serum can be used as a marker of hemolysis.
5% of RBCs) Antigoblin tests Positive (Negative) (in immune types) Serum haptoglobin Decreased (40 to 240 mg/dL) Plasma free Hb Increased (100 to 210 IU/L) Heinz bodies Present (Absent)
Beyond a certain concentration of Hb, according to its concentration and phenotype, serum Hp becomes saturated and free Hb appears.
In anhaptoglobinemia, serum hemopexin acts as a back-up scavenger molecule to protect the individual from the toxic effects of free Hb.
Among them, haptoglobin (Hp) is a plasma protein responsible for the removal of free Hb from the circulation (3).
Therefore, the increased binding of NO, which could result from increased free Hb in thalassemic patients or from the presence of an intraerythrocytic Hb species that binds significantly more NO than Hb A, could result in transient or sustained increases in blood pressure.