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[Sanders T. Frank, U.S. pulmonologist, b. 1938]
A crease that extends diagonally across both ear lobes. It has been linked as a marker in some studies with coronary artery disease or diabetic vascular disease.
Frank,Sanders T., U.S. thoracic physician, 1938–.
Frank sign - oblique earlobe fissure associated with hypertension, heart disease, and diabetes; acquired as opposed to congenital.