Framingham Heart Study


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Framingham Heart Study

 
a longitudinal study begun in 1948 in which there is and has been continuous gathering of data on the health and habits of the adult inhabitants of Framingham, Massachusetts. Data from this study have shown relationships between cardiovascular disease and such variables as smoking, diet, lack of exercise, and other facets of a person's lifestyle.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

Fram·ing·ham Heart Stud·y

the first major U.S. study of the epidemiology of cardiovascular disease, begun in Framingham, Massachusetts, in 1948 under the auspices of the National Heart Institute (now the National Heart, Lung, and Blood Institute) and still in operation. Initially the Framingham researchers enrolled 5209 men and women between the ages of 30 and 60 to study the evolution of heart disease and identify risk factors for heart attack. In 1971, the Framingham Offspring Study enrolled 5,124 adult children of original study participants along with their spouses, and in 2001 the Third Generation Study recruited some 3,500 grandchildren of original enrollees.

Framingham, about 20 miles west of Boston, was chosen as the site of this long-term epidemiologic study because it was close to major medical centers and had participated in an earlier population-based investigation of tuberculosis. Participants undergo periodic physical examination, electrocardiography, and laboratory testing. The Framingham study has produced more than 1,000 scientific papers and has had a major impact on the modern understanding of cardiovascular disease and the prevention and treatment not only of heart attack but also of stroke. During the 1960s, cigarette smoking, elevated cholesterol, hypertension, obesity, and lack of exercise were all statistically confirmed to be risk factors for heart attack. In succeeding years, the study provided valuable information on triglycerides, LDL cholesterol, mitral valve prolapse, heart failure, atrial fibrillation, stroke, diabetes, cardiovascular risk factors in ethnic minorities, and the role of estrogen in preventing heart attack in postmenopausal women. The current emphasis is on identifying genetic and molecular risk factors for heart disease and other cardiovascular disorders.

Farlex Partner Medical Dictionary © Farlex 2012

Framingham Heart Study

, Framingham Study [named for Framingham, MA, the town where the investigation took place]
A study of the risk factors that contribute to the development of coronary artery disease and stroke, performed with a group of about 5000 residents of a small New England town under the auspices of the National Institutes of Health (National Heart, Lung, and Blood Institute). The study began shortly after World War II and has followed a cohort of individuals, aged 30-62, for signs and symptoms of atherosclerotic vascular disease and those physical findings and lifestyle choices that contribute to the development of the disease. In 1971, 5124 children of the original cohort were enrolled in the study, and in 2002, a third generation of townspeople were enrolled in an attempt to further understand genetic factors that contribute to the development of heart attack and stroke. The Framingham study identified the major acknowledged risk factors for vascular disease: diabetes, high blood pressure, hyperlipidemia, obesity, a sedentary lifestyle, and smoking. The Framingham database has also been used to explore illnesses other than heart disease, including arthritis, dementia, lung disease, osteoporosis, and a wide variety of genetic illnesses.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Disclosures: The Framingham Heart Study is funded by the National Heart, Lung, and Blood Institute.
In lieu of flowers, donations may be made to Arthritis Foundation, 1330 West Peachtree St., NW Suite 100 Atlanta, Georgia 30309, or Framingham Heart Study, 73 Mt.
The Framingham Heart Study looked at many other biochemical markers for cardiovascular risk and put them together into multimarker scores to predict low, intermediate, or high risk (N.
CHICAGO -- The Framingham Heart Study risk algorithm fails to identify a significant number of individuals at high risk of coronary heart disease, and its accuracy could be improved significantly by integrating coronary calcium scoring, according to a new study from the Netherlands.
Scientists at the Jean Mayer USDA Human Nutrition Research Center on Aging (USDA HNRCA) at Tufts University and Boston University School of Medicine found a link between low plasma cholesterol ester transfer protein (CETP) activity and increased risk of heart disease in the Framingham Heart Study population.
Wrong, says William Castelli, director of the Framingham Heart Study. If you have a low HDL ("good") cholesterol level, you may still be at risk.
Knowing the man had participated in the Framingham Heart Study, the coroner phoned the study's research office to ask whether the victim's medical history might suggest a heart attack risk.
Memorial Contributions may be made to the Framingham Heart Study, 73 Mount Wayte Ave., # 2 Framingham, MA 01701.
The Framingham Heart Study Offspring Cohort enrolled 5,124 children and spouses of the original Framingham cohort.
The Framingham Heart Study looked at a host of other biochemical markers for cardiovascular risk and put them together into multimarker scores to predict low, intermediate, or high risk (N.
According to researchers from the Framingham Heart Study, the thickness of an individual's neck may provide clues to their risk of developing heart problems.
One is an analysis of data from the Framingham Heart Study, a collection of medical information regarding the inhabitants of a Massachusetts town.