frameshift mutation

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read·ing-·frame·shift mu·ta·tion

a mutation that results from insertion or deletion of a single nucleotide into, or from, the normal DNA sequence; because the genetic code is read three nucleotides at a time, all nucleotide triplets distal to the mutation will be one step out of phase and misread, and hence translated as different amino acids.

frameshift mutation

(frām′shĭft′)
n.
A mutation in a DNA chain that occurs when the number of nucleotides inserted or deleted is not a multiple of three, so that every codon beyond the point of insertion or deletion is read incorrectly during translation.

frameshift mutation

The deletion or insertion of one or two DNA nucleotides that alters the transcription of each subsequent triplet.
See also: mutation
References in periodicals archive ?
Solenopsis invicta virus 3: mapping of structural proteins, ribosomal frameshifting, and similarities to Acyrthosiphon pisum virus and Kelp fly virus.
Evidence for ribosomal frameshifting and a novel overlapping gene in the genomes of insect-specific flaviviruses.
Furthermore, additional sequence was inserted immediately after the ochre codon to create proximal ochre codons in the two remaining forward reading frames; this served to more promptly terminate translation arising from exonic frameshifting mutations, but this attribute was not necessary for the detection of any of the analytes described in this report.